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Fig. 6 | BMC Cancer

Fig. 6

From: Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness

Fig. 6

Schematic image of the potential role of miR-182-5p in homologous recombination deficiency. The up-regulation of cell-free miR-182-5p in plasma samples of BC patients could be a non-invasive predictive biomarker for using PARP inhibitor or DNA damaging chemotherapy. The high expression of miR-182-5p could decrease some critical HRR-related genes, such as CHEK2, RAD51. HRR: homologous recombination repair; SSB: single-strand break; DSB: double-strand break; NHEJ: non-homologous end joining; PARP: Poly (ADP-ribose) polymerase

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BMC Cancer

ISSN: 1471-2407

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