Table 3 Parameters of the multivariate Cox proportional regression model for six key CAF markers and CAFs. TCGA data for stomach adenocarcinoma samples were analyzed in the TIMER2.0 immune association - outcome module using the TIDE algorithm for the allocation of samples to the high vs. low CAF infiltration groups. Likelihood ratio and Score log-rank tests were performed (CAF: cancer-associated fibroblast, CI: confidence interval, HR: hazard ratio)

CAF

5.240

2.004–13.702

3.377

0.001

CAF, COL1A1

5.430

1.392–21.179

2.437

0.015

CAF, COL1A2

5.631

1.218–26.033

2.212

0.027

CAF, COL3A1

5.916

1.078–32.465

2.047

0.041

CAF, COL5A1

8.584

1.767–41.695

2.666

0.008

CAF, FN1

4.247

0.956–18.880

1.900

0.057

CAF, SPARC

3.042

0.599–0.878

1.342

0.180

CAF, COL1A1, COL1A2

5.789

1.164–28.802

2.145

0.032

CAF, COL1A1, COL3A1

6.167

1.034–36.775

1.997

0.046

CAF, COL1A1, COL5A1

11.654

2.247–60.438

2.924

0.003

CAF, COL1A2, COL3A1

5.968

1.074–33.168

2.041

0.041

CAF, COL1A2, COL5A1

7.701

1.550–38.253

2.496

0.013

CAF, COL3A1, COL5A1

6.339

1.151–34.913

2.121

0.034

CAF, COL1A1, COL1A2, COL3A1, COL5A1

10.176

1.532–67.610

2.401

0.016