Fig. 3

Protein-protein interaction (PPI) network of 83 differentially expresses genes in gastric cancer. A PPI network graph constructed in STRING. (Line colors indicate the type of interaction evidence; edges indicate functional and physical protein associations. Minimum required interaction score: high confidence (0.7). Disconnected nodes are hidden in the network). B Degree sorted circular network graph constructed in Cytoscape. Black arrows show the two genes with the highest degree in the network. The degrees of the nodes decrease counterclockwise. C Modules in the protein-protein interaction network of 83 differentially expressed genes in gastric cancer. Module analysis was performed using the MCODE tool in Cytoscape. The scores, number of nodes, and edges for each module are listed in the D Neighbors of the six CAF markers COL1A1 (orange), COL1A2 (orange), COL3A1 (red), COL5A1 (yellow), FN1(red), and SPARC (yellow). The network was constructed using the Cytohubba tool in Cytoscape (Color grade from red to yellow indicates the descending order of node degrees in the network)