Fig. 10

Prognostic impact and the expression profile of the cancer-associated fibroblast signature genes. A The hazard ratios of CAF infiltration for different gene expression profiles in STAD. C1: COL1A1, C5: COL5A1, I4: ITGA4, E1: EMILIN1, F1: FN1 and T9: TSPAN9. Bars indicate 95% confidence intervals. Data was extracted from TIMER2.0. B Gene expression profile for COL1A1, COL5A1, ITGA4, EMILIN1, and TSPAN9 in ACC, KIRP, MESO, and STAD. Symbols show the medians for transcripts per million (TPM) in each cancer at the TCGA dataset. Data was extracted from UALCAN. C Correlation between CAF infiltration and the expression of COL1A1, COL5A1, ITGA4, EMILIN1, and TSPAN9 in ACC, KIRP, MESO, and STAD. Data was extracted from TIMER2.0. using the TIDE algorithm. Differential expression of D ITGA4, E EMILIN1, and F TSPAN9 by tumor stage in primary STAD. The TCGA data, which includes 34 normal tissues and 415 primary stomach adenocarcinoma tissues, was used for analysis. Analysis was performed on UALCAN (unpaired t-test, * p < 0.05, ** p < 0.01, *** p < 0.001). (ACC: adrenocortical carcinoma, BLCA: bladder urothelial carcinoma, KIRP: kidney renal papillary cell carcinoma, MESO: mesothelioma, and STAD: stomach adenocarcinoma)