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Table 3 Univariate and stepwise multivariate logistic regression analyses of clinicopathological factors that related to death within 1-year in advanced oropharyngeal cancer patients

From: A predictive model for advanced oropharyngeal cancer patients treated with chemoradiation

 

Univariate

Multivariate

OR

95% CI

p-value

OR

95% CI

p-value

Gender

 Female

Ref.

   

Ref.

   

 Male

3.031

0.362

25.412

0.307

2.386

0.249

22.817

0.450

Age

  < 60y

Ref.

   

Ref.

   

  ≥ 60y

1.698

0.830

3.473

0.147

2.200

0.881

5.495

0.091

T

 T1 + 2

Ref.

       

 T3 + 4

3.625

1.476

8.906

0.005*

    

N

 N0 + 1

Ref.

   

Ref.

   

 N2

1.202

0.500

2.892

0.681

1.050

0.292

3.774

0.940

 N3

3.625

1.080

12.167

0.037*

1.552

0.267

9.023

0.624

Stage

 III

Ref.

   

Ref.

   

 IVa

0.925

0.275

3.109

0.900

0.575

0.104

3.172

0.525

 IVb

6.250

1.678

23.275

0.006*

2.700

0.391

18.629

0.314

Subsite

 Tonsil

Ref.

       

 Soft palate

0.552

0.113

2.695

0.463

    

 Tongue base

0.753

0.194

2.921

0.681

    

 Pharyngeal wall

2.563

1.060

6.196

0.037*

    

Side

 R

Ref.

       

 L

1.019

0.496

2.092

0.960

    

Previous treated cancer

 None

Ref.

       

 Yes

0.705

0.184

2.698

0.610

    

Syn−/Meta-chornous cancer

 None

Ref.

       

 Yes

1.250

0.466

3.351

0.657

    

Differentiation

 Well

Ref.

       

 Moderately + Poorly

0.705

0.345

1.441

0.338

    

HPV (p16)

 Positive

Ref.

       

 Negative

1.455

0.447

4.733

0.534

    

Smoking habit

 No

Ref.

       

 Yes, quitted

1.022

0.374

2.798

0.966

    

 Yes, persistence

0.894

0.365

2.194

0.808

    

BMI

  < 22

Ref.

       

  ≥ 22

0.365

0.176

0.758

0.007*

    

Hemoglobulin (gm/dl)

  ≥ 13.5

Ref.

   

Ref.

   

  < 13.5

6.206

2.622

14.689

0.000*

5.846

2.169

15.754

0.000*

Lymphocyte count (103/μl)

  ≥ 1.85

Ref.

       

  < 1.85

1.690

0.792

3.606

0.175

    

Monocyte count (102/μl)

  < 0.56

Ref.

       

  ≥ 0.56

1.354

0.663

2.765

0.405

    

Platelet count (103/μl)

  < 239

Ref.

       

  ≥ 239

5.152

2.243

11.830

0.000*

    

Neutrophil count (103/μl)

  < 7.5

Ref.

       

  ≥ 7.5

3.124

1.411

6.917

0.005*

    

LMR

  < 1.9

Ref.

       

  ≥ 1.9

0.692

0.313

1.533

0.364

    

PLR

  < 157

Ref.

       

  ≥ 157

2.100

1.004

4.373

0.049*

    

NLR

  < 5.1

Ref.

       

  ≥ 5.1

2.149

1.024

4.511

0.043*

    

SIRI

  < 553.7

Ref.

       

  ≥ 553.7

4.199

1.479

11.922

0.007*

    

SII

  <  1820

Ref.

   

Ref.

   

  ≥ 1820

8.212

3.066

21.995

0.000*

4.777

1.440

15.846

0.011*

  1. *: p < 0.05
  2. LMR Lymphocyte to monocyte ratio, PLR Platelet to lymphocyte ratio, NLR Neutrophil to lymphocyte ratio, SII Systemic immune inflammation, SIRI Systemic inflammation response index