Table 3 Biomarkers identified as prognostic for worse outcomes by more than one study

Univariable analysis

Outcome

(number of studies reporting outcome)

Factor

Times identified as prognostic

Total times tested

Studies which identified factor as prognostic

Overall survival

(n = 17)

Lower HPV16 load

2

3

[27, 28]

Neutrophilia

2

2

[29, 36]

Anaemia

2

2

[29, 36]

Locoregional failure

(n = 11)

Lower HPV16 load

2

3

[27, 28]

Disease-free survival

(n = 11)

Leukocytosis

2

2

[29, 36]

Neutrophilia

2

2

[29, 36]

Multivariable analysis

Outcome

(number of studies reporting outcome)

Factor

Times identified as prognostic

Factor effect range (HR)

Studies which identified factor as prognostic

Overall survival

(n = 17)

Leukocytosis

2

4.60 – 19.90

[29, 36]

Neutrophilia

2

4.40 – 22.70

[29, 36]

Locoregional failure

(n = 11)

Lower HPV16 load

2

3.57 – 4.51

[27, 28]

Disease-free survival

(n = 11)

Leukocytosis

2

6.90 – 7.10

[29, 36]

Neutrophilia

2

5.00 – 7.60

[29, 36]

Anaemia

2

2.50 – 5.30

[29, 36]