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Fig. 3 | BMC Cancer

Fig. 3

From: Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS)

Fig. 3

A Verification of specific hairpin-induced ASPP2κ-interference using isoform-specific qRT-PCR. EV, empty vector. Statistical test: unpaired t-test. B, C Induction of apoptosis upon treatment with doxorubicin in ASPP2κ-interferenced RD and ssRMS cells, when compared to the respective EV control stains. Statistical test: two-way ANOVA. ****p < 0.0001, ***p < 0.001, ** p < 0.01, *p < 0.05. D, E Computed logIC50 and IC50 values of shASPP2κ or shEV.RD, resp. ssRMS, cell strains in response to doxorubicin 

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BMC Cancer

ISSN: 1471-2407

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