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Fig. 6 | BMC Cancer

Fig. 6

From: MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

Fig. 6

The activity of MIF inhibitors on neuroblastoma cell lines and BM primary cultures. Cytotoxic activity of A) AMD3100 (50-0.0001 μM), B) ISO-1 (50-0.2 μM) and C) 4-IPP (50-0.2 μM) in a panel NB cell lines and BM primary culture under regular conditions (n = 6). Flow cytometry quantification in bar graphs of 4-IPP activity on D) BM, E) LAN-1, and F) co-cultures LAN1:BM ratio (1:10) treated with vehicle or 4-IPP 30 μM after 72 h at regular conditions (n = 2)

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BMC Cancer

ISSN: 1471-2407

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