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Table 2 Multivariable analysis of OS, DMFS, and LRRFS for low LARC patients treated with NRT

From: Necessity of external iliac lymph nodes and inguinal nodes radiation in rectal cancer with anal canal involvement

variables

OS

DFS

LRFS

DMFS

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

Gender

Female

Ref

 

Ref

 

Ref

 

Ref

 

Male

1.14

(0.66- 1.95)

0.643

1.19

(0.75–1.89)

0.461

1.20

(0.71–2.04)

0.499

1.17

(0.73–1.86)

0.518

Age

 < 60

Ref

 

Ref

 

Ref

 

Ref

 

 ≥ 60

1.52

(0.86–2.67)

0.146

1.50

(0.92–2.44)

0.103

1.67

(0.97–2.88)

0.065

1.39

(0.85–2.28)

0.190

CEA

 ≤ 5

Ref

 

Ref

 

Ref

 

Ref

 

 > 5

1.00

(1.00–1.01)

0.358

1.00

(1.00–1.01)

0.435

1.00

(1.00–1.01)

0.596

1.00

(1.00–1.01)

0.355

CA199

 ≤ 37

Ref

 

Ref

 

Ref

 

Ref

 

 > 37

1.00

(1.00- 1.01)

0.414

1.00

(1.00–1.00)

0.878

1.00

(1.00–1.00)

0.567

1.00

(1.00–1.00)

0.810

Concurrent chemotherapy regimen

Single

Ref

 

Ref

 

Ref

 

Ref

 

Combined

0.89

(0.50- 1.59)

0.702

0.80

(0.49–1.32)

0.386

0.83

(0.47–1.46)

0.517

0.85

(0.51–1.40)

0.523

None

0.29

(0.07- 1.22)

0.092

0.04

(1.4e-4–8.95)

0.237

0.24

(0.49–1.16)

0.076

0.05

(0.00–8.25)

0.249

Postoperative chemotherapy

No

Ref

 

Ref

 

Ref

 

Ref

 

Yes

0.82

(0.42–1.60)

0.559

1.11

(0.61–1.99)

0.741

0.96

(0.49–1.86)

0.897

0.99

(0.55–1.77)

0.972

Number of lymph nodes

 < 12

Ref

 

Ref

 

Ref

 

Ref

 

 ≥ 12

0.94

(0.56–1.60)

0.823

0.92

(0.58–1.46)

0.713

0.92

(0.55–1.53)

0.748

0.96

(0.60–1.55)

0.878

none

1.2e-7

(3.3e-8–4.6e-7)

 < 2e-16 ***

1.2e-7

(3.6e-8–3.9e-7)

 < 2e-16 ***

1.3e-7

(3.5e-8–4.6e-7)

 < 2e-16 ***

1.1e-7

(3.4e-8–3.8e-7)

 < 2e-16 ***

Radiotherapy

LCRT

Ref

 

Ref

 

Ref

 

Ref

 

LCRT + SIB

0.70

(0.28–1.77)

0.447

0.81

(0.34–1.89)

0.618

0.76

(0.31–1.86)

0.542

0.77

(0.33–1.80)

0.542

SCRT3

4.77

(0.93–24.52)

0.062

29.33

(0.14–62.55)

0.217

5.54

(0.98–31.49)

0.053

22.37

(0.15–33.03)

0.223

Pathological stage

ypCR 0

Ref

 

Ref

 

Ref

 

Ref

 

ypI

0.49

(0.15–1.55)

0.222

0.95

(0.39–2.33)

0.913

0.65

(0.22–1.90)

0.431

0.79

(0.31–2.01)

0.615

ypII

1.94

(0.81–4.65)

0.138

2.31

(1.07–4.98)

0.033 **

1.95

(0.84–4.55)

0.120

2.34

(1.07–5.11)

0.033

*

ypIII

3.64

(1.59- 8.34)

0.002 **

4.48

(2.15–9334)

6.08e-05 ***

3.83

(1.70–8.61)

0.001 ***

4.32

(2.06–9.09)

0.0001 ***

Anal canal

Rb group

Ref

 

Ref

 

Ref

 

Ref

 

P group

1.30

(0.76–2.22)

0.336

1.31

(0.82–2.08)

0.260

1.29

(0.76–2.19)

0.346

1.23

(0.78–1.96)

0.374