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Table 2 Multivariable analysis of OS, DMFS, and LRRFS for low LARC patients treated with NRT

From: Necessity of external iliac lymph nodes and inguinal nodes radiation in rectal cancer with anal canal involvement

variables OS DFS LRFS DMFS
HR (95% CI) p HR (95% CI) p HR (95% CI) p HR (95% CI) p
Gender
Female Ref   Ref   Ref   Ref  
Male 1.14
(0.66- 1.95)
0.643 1.19
(0.75–1.89)
0.461 1.20
(0.71–2.04)
0.499 1.17
(0.73–1.86)
0.518
Age
 < 60 Ref   Ref   Ref   Ref  
 ≥ 60 1.52
(0.86–2.67)
0.146 1.50
(0.92–2.44)
0.103 1.67
(0.97–2.88)
0.065 1.39
(0.85–2.28)
0.190
CEA
 ≤ 5 Ref   Ref   Ref   Ref  
 > 5 1.00
(1.00–1.01)
0.358 1.00
(1.00–1.01)
0.435 1.00
(1.00–1.01)
0.596 1.00
(1.00–1.01)
0.355
CA199
 ≤ 37 Ref   Ref   Ref   Ref  
 > 37 1.00
(1.00- 1.01)
0.414 1.00
(1.00–1.00)
0.878 1.00
(1.00–1.00)
0.567 1.00
(1.00–1.00)
0.810
Concurrent chemotherapy regimen
Single Ref   Ref   Ref   Ref  
Combined 0.89
(0.50- 1.59)
0.702 0.80
(0.49–1.32)
0.386 0.83
(0.47–1.46)
0.517 0.85
(0.51–1.40)
0.523
None 0.29
(0.07- 1.22)
0.092 0.04
(1.4e-4–8.95)
0.237 0.24
(0.49–1.16)
0.076 0.05
(0.00–8.25)
0.249
Postoperative chemotherapy
No Ref   Ref   Ref   Ref  
Yes 0.82
(0.42–1.60)
0.559 1.11
(0.61–1.99)
0.741 0.96
(0.49–1.86)
0.897 0.99
(0.55–1.77)
0.972
Number of lymph nodes
 < 12 Ref   Ref   Ref   Ref  
 ≥ 12 0.94
(0.56–1.60)
0.823 0.92
(0.58–1.46)
0.713 0.92
(0.55–1.53)
0.748 0.96
(0.60–1.55)
0.878
none 1.2e-7
(3.3e-8–4.6e-7)
 < 2e-16 *** 1.2e-7
(3.6e-8–3.9e-7)
 < 2e-16 *** 1.3e-7
(3.5e-8–4.6e-7)
 < 2e-16 *** 1.1e-7
(3.4e-8–3.8e-7)
 < 2e-16 ***
Radiotherapy
LCRT Ref   Ref   Ref   Ref  
LCRT + SIB 0.70
(0.28–1.77)
0.447 0.81
(0.34–1.89)
0.618 0.76
(0.31–1.86)
0.542 0.77
(0.33–1.80)
0.542
SCRT3 4.77
(0.93–24.52)
0.062 29.33
(0.14–62.55)
0.217 5.54
(0.98–31.49)
0.053 22.37
(0.15–33.03)
0.223
Pathological stage
ypCR 0 Ref   Ref   Ref   Ref  
ypI 0.49
(0.15–1.55)
0.222 0.95
(0.39–2.33)
0.913 0.65
(0.22–1.90)
0.431 0.79
(0.31–2.01)
0.615
ypII 1.94
(0.81–4.65)
0.138 2.31
(1.07–4.98)
0.033 ** 1.95
(0.84–4.55)
0.120 2.34
(1.07–5.11)
0.033
*
ypIII 3.64
(1.59- 8.34)
0.002 ** 4.48
(2.15–9334)
6.08e-05 *** 3.83
(1.70–8.61)
0.001 *** 4.32
(2.06–9.09)
0.0001 ***
Anal canal
Rb group Ref   Ref   Ref   Ref  
P group 1.30
(0.76–2.22)
0.336 1.31
(0.82–2.08)
0.260 1.29
(0.76–2.19)
0.346 1.23
(0.78–1.96)
0.374