Table 2 Multivariable analysis of OS, DMFS, and LRRFS for low LARC patients treated with NRT

Gender

Female

Ref

Ref

Ref

Ref

Male

1.14

(0.66- 1.95)

0.643

1.19

(0.75–1.89)

0.461

1.20

(0.71–2.04)

0.499

1.17

(0.73–1.86)

0.518

Age

 < 60

Ref

Ref

Ref

Ref

 ≥ 60

1.52

(0.86–2.67)

0.146

1.50

(0.92–2.44)

0.103

1.67

(0.97–2.88)

0.065

1.39

(0.85–2.28)

0.190

CEA

 ≤ 5

Ref

Ref

Ref

Ref

 > 5

1.00

(1.00–1.01)

0.358

1.00

(1.00–1.01)

0.435

1.00

(1.00–1.01)

0.596

1.00

(1.00–1.01)

0.355

CA199

 ≤ 37

Ref

Ref

Ref

Ref

 > 37

1.00

(1.00- 1.01)

0.414

1.00

(1.00–1.00)

0.878

1.00

(1.00–1.00)

0.567

1.00

(1.00–1.00)

0.810

Concurrent chemotherapy regimen

Single

Ref

Ref

Ref

Ref

Combined

0.89

(0.50- 1.59)

0.702

0.80

(0.49–1.32)

0.386

0.83

(0.47–1.46)

0.517

0.85

(0.51–1.40)

0.523

None

0.29

(0.07- 1.22)

0.092

0.04

(1.4e-4–8.95)

0.237

0.24

(0.49–1.16)

0.076

0.05

(0.00–8.25)

0.249

Postoperative chemotherapy

No

Ref

Ref

Ref

Ref

Yes

0.82

(0.42–1.60)

0.559

1.11

(0.61–1.99)

0.741

0.96

(0.49–1.86)

0.897

0.99

(0.55–1.77)

0.972

Number of lymph nodes

 < 12

Ref

Ref

Ref

Ref

 ≥ 12

0.94

(0.56–1.60)

0.823

0.92

(0.58–1.46)

0.713

0.92

(0.55–1.53)

0.748

0.96

(0.60–1.55)

0.878

none

1.2e-7

(3.3e-8–4.6e-7)

 < 2e-16 ***

1.2e-7

(3.6e-8–3.9e-7)

 < 2e-16 ***

1.3e-7

(3.5e-8–4.6e-7)

 < 2e-16 ***

1.1e-7

(3.4e-8–3.8e-7)

 < 2e-16 ***

Radiotherapy

LCRT

Ref

Ref

Ref

Ref

LCRT + SIB

0.70

(0.28–1.77)

0.447

0.81

(0.34–1.89)

0.618

0.76

(0.31–1.86)

0.542

0.77

(0.33–1.80)

0.542

SCRT3

4.77

(0.93–24.52)

0.062

29.33

(0.14–62.55)

0.217

5.54

(0.98–31.49)

0.053

22.37

(0.15–33.03)

0.223

Pathological stage

ypCR 0

Ref

Ref

Ref

Ref

ypI

0.49

(0.15–1.55)

0.222

0.95

(0.39–2.33)

0.913

0.65

(0.22–1.90)

0.431

0.79

(0.31–2.01)

0.615

ypII

1.94

(0.81–4.65)

0.138

2.31

(1.07–4.98)

0.033 **

1.95

(0.84–4.55)

0.120

2.34

(1.07–5.11)

0.033

*

ypIII

3.64

(1.59- 8.34)

0.002 **

4.48

(2.15–9334)

6.08e-05 ***

3.83

(1.70–8.61)

0.001 ***

4.32

(2.06–9.09)

0.0001 ***

Anal canal

Rb group

Ref

Ref

Ref

Ref

P group

1.30

(0.76–2.22)

0.336

1.31

(0.82–2.08)

0.260

1.29

(0.76–2.19)

0.346

1.23

(0.78–1.96)

0.374