Table 3 Grade 3–4 acute toxicities during treatment
Advese event (grade3-4) | Availability | Effect | Heterogeneity | Analysis model | ||||
|---|---|---|---|---|---|---|---|---|
Trials (N) | Other platinum (events/total) | Cisplatin (events/total) | RR (95% CI) | P value | I2 | P value | Â | |
Hematological | ||||||||
 neutropenia | 5 | 210/781 | 169/753 | 1.21(0.94–1.57) | 0.14 | 53% | 0.07 | Random effect |
 leucopenia | 5 | 177/773 | 173/744 | 0.97(0.81–1.17) | 0.78 | 45% | 0.12 | Fixed effect |
 thrombocytopenia | 6 | 88/886 | 56/854 | 1.62(0.98–2.69) | 0.06 | 51% | 0.07 | Random effect |
 anemia | 5 | 26/783 | 77/771 | 0.30(0.12–0.77) | 0.01 | 72% | 0.007 | Random effect |
Nonhematologic | ||||||||
 xerostomia | 5 | 28/773 | 33/741 | 0.83(0.51–1.35) | 0.46 | 0% | 0.48 | Fixed effect |
 dermatitis | 4 | 24/573 | 22/543 | 1.02(0.58–1.81) | 0.95 | 0% | 0.4 | Fixed effect |
 mucositis | 6 | 211/886 | 227/854 | 0.91(0.78–1.06) | 0.23 | 27% | 0.24 | Fixed effect |
 nausea | 3 | 8/555 | 62/530 | 0.12(0.06–0.25) |  < 0.0001 | 0% | 0.41 | Fixed effect |
 vomiting | 5 | 22/781 | 125/753 | 0.15(0.06–0.40) | 0.0001 | 61% | 0.04 | Random effect |
 weight loss | 3 | 4/468 | 12/445 | 0.34(0.12–0.98) | 0.05 | 30% | 0.24 | Fixed effect |
 Elevation of aminotransferase | 2 | 6/135 | 7/114 | 0.71(0.25–2.05) | 0.53 | 0% | 0.81 | Fixed effect |