From: Meta-analysis of diagnostic cell-free circulating microRNAs for breast cancer detection
Authors | Year | Countrya | Source | Sample size (Healthy controls + benign)b | Index test (model) | Diagnostic Performancec |
---|---|---|---|---|---|---|
Swellam et al. [36] | 2019 | Egypt | Serum | 182 (39 + 47) | - miR-21 | 0.857 |
- miR-126 | 0.998 | |||||
- miR-155 | 0.995 | |||||
111 (39 + 47)d | - miR-21 | 0.400/0.930 | ||||
- miR-126 | 0.760/1.000 | |||||
- miR-155 | 0.958/0.965 | |||||
Zhang et al. [37] | 2017 | China | Whole Blood | 28 (13) | - miR-30b-5p | 0.933 |
- miR-96-5p | 0.769 | |||||
- miR-182-5p | 0.759 | |||||
- miR-374b-5p | 0.826 | |||||
- miR-942-5p | 0.813 | |||||
Mar-Aguilar et al. [38] | 2013 | Mexico | Serum | 71 (10) | - miR-10b | 0.950 |
- miR-21 | 0.950 | |||||
- miR-125b | 0.950 | |||||
- miR-145 | 0.978 | |||||
- miR-155 | 0.994 | |||||
- miR-191 | 0.794 | |||||
- miR-382 | 0.967 | |||||
- miR-145/miR-155/miR-382 | 0.988 | |||||
Wu et al. [39] | 2012 | China | Serum | 100 (50) | - miR-222-3p | 0.670 |
Diansyah et al. [40] | 2021 | Indonesia | Plasma | 42 (16) | - miR-21 | 0.923 |
Hosseini Mojahed et al. [41] | 2020 | Iran | Serum | 72 (36) | - miR-155 | 0.890 |
Pena-Cano et al. [42] | 2019 | Mexico | Serum | 100 (50) | - miR-195-5p | 0.882 |
Kim et al. [43] | 2020 | South Korea | Plasma | 60 (30) | - miR-202 | 0.950 |
Heydari et al. [44] | 2018 | Iran | Serum | 80 (40) | - miR-140-3p | 0.660 |
Motamedi et al. [45] | 2019 | Iran | Plasma | 47 (24) | - miR-21 | 0.828 |
Swellam et al. [46] | 2019 | Egypt | Serum | 150 (30 + 40) | - miR-17-5p | 0.871 |
- miR-155 | 0.993 | |||||
- miR-222-3p | 0.863 | |||||
103 (30 + 40)d | - miR-17-5p | 1.000/0.757 | ||||
- miR-155 | 0.935/0.944 | |||||
- miR-222-3p | 1.000/0.786 | |||||
Matamala et al. [47] | 2015 | Spain | Plasma | 230 (116) | - miR-505-5p | 0.721 |
- miR-96-5p | 0.717 | |||||
- miR-125b-5p | 0.637 | |||||
- miR-21 | 0.607 | |||||
Li et al. [48] | 2019 | China | Plasma | 226 (113) | - let-7b-5p/miR-122-5p/miR-146-5p/miR-210-3p/miR-215-5p | 0.966 |
Han et al. [49] | 2017 | China | Serum | 120 (21) | - miR-21 | 0.788 |
71 (21) | - miR-125b | 0.559 | ||||
120 (21) | - miR-145 | 0.587 | ||||
70 (21) | - miR-155 | 0.749 | ||||
120 (21) | - miR-365 | 0.795 | ||||
70 (21) | - miR-21/miR-155 | 0.868 | ||||
70 (21) | - miR-21/miR-155/miR-365 | 0.918 | ||||
120 (21) | - miR-21/miR-365 | 0.868 | ||||
Zhao et al. [50] | 2010 | USA | Plasma | 30 (15) | - let-7c | 0.780 |
30 (15) | - miR-589 | 0.850 | ||||
20 (10) | - miR-425 | 0.830 | ||||
20 (10) | - let-7d | 0.990 | ||||
Pastor-Navarro et al. [51] | 2020 | Spain | Serum | 90 (45) | - miR-21/miR-205 | 0.773 |
- miR-21 | 0.771 | |||||
- miR-205 | 0.649 | |||||
Si et al. [52] | 2013 | China | Serum | 120 (20) | - miR-92a | 0.923 |
- miR-21 | 0.933 | |||||
Freres et al. [53] | 2015 | Belgium | Plasma | 196 (88) | - miR-16/let-7d/miR-103/miR-107/miR-148a/let-7i/miR-19b/miR-22* | 0.810 |
- miR-16/let-7d/miR-103/miR-181a/miR-107/miR-142-3p/miR-148a/let-7f-1/miR-199a-5p/miR-590-5p/miR-32 | 0.800 | |||||
Schrauder et al. [54] | 2012 | Germany | Whole Blood | 48 (24) | - miR-202 | 0.680 |
Ng et al. [55] | 2013 | China | Plasma | 120 (50) | - miR-145/miR-451a | 0.931 |
Li et al. [56] | 2018 | China | Plasma | 292 (146) | - miR-106a-3p/miR-106a-5p/miR-20b-5p/miR-92a-5p | 0.826 |
Serum | 298 (148) | - miR-106a-5p/miR-19b-3p/miR-20b-5p/miR-92a-3p | 0.965 | |||
Shen et al. [57] | 2014 | USA | Serum | 100 (50) | - miR-133a/miR-148b | 0.860 |
Antolin et al. [58] | 2015 | Spain | Whole Blood | 64 (20) | - miR-200c | 0.850 |
37 (20) | - miR-200c | 0.820 | ||||
Soleimanpour et al. [59] | 2019 | Iran | Plasma | 60 (30) | - miR-21 | 0.990 |
- miR-155 | 0.920 | |||||
Nashtahosseini et al. [60] | 2021 | Iran | Serum | 72 (38) | - miR-660-5p | 0.774 |
62 (38)d | - miR-660-5p | 0.816 | ||||
72 (38) | - miR-210-3p | 0.716 | ||||
62 (38)d | - miR-210-3p | 0.652 | ||||
Han et al. [61] | 2020 | China | Serum | 182 (38) | - miR-1204 | 0.823 |
Chen et al. [18] | 2016 | USA | Plasma | 102 (49) | - miR-21 | 0.613 |
- miR-152 | 0.687 | |||||
Yu et al. [62] | 2018 | China | Serum | 160 (47) | - miR-21-5p/miR-21-3p/miR-99a-5p | 0.895 |
Zou et al. [63] | 2021 | China | Serum | 246 (122) | - let-7b-5p/miR-106a-5p/miR-16-5p/miR-19a-3p/miR-19b-3p/miR-20a-5p/miR-223-3p/miR-25-3p/miR-425-5p/miR-451a/miR-92a-3p/miR-93-5p | 0.956 |
Fang et al. [64] | 2019 | China | Plasma | 131 (38 + 40) | - miR-324-3p/miR-382-5p/miR-21-3p/miR-324-3p/miR-30a-5p/miR-30e-5p/miR-221-3p/miR-324-3p | 0.901 |
- miR-324-3p/miR-382-5p/miR-21-3p/miR-324-3p/miR-30a-5p/miR-30e-5p/miR-221-3p/miR-324-3p | 0.820 | |||||
An et al. [65] | 2018 | China | Serum | 109 (24) | - miR-24 | 0.716 |
- miR-103a | 0.721 | |||||
Hu et al. [66] | 2012 | China | Serum | 152 (76) | - miR-16/miR-25/miR-222/miR-324-5p | 0.928 |
Zhang et al. [67] | 2015 | China | Serum | 151 (93) | - miR-205 | 0.840 |
Eichelser et al. [68] | 2013 | Germany | Serum | 160 (40) | - miR-34a | 0.636 |
- miR-93 | 0.699 | |||||
- miR-373 | 0.879 | |||||
Wang et al. [69] | 2018 | China | Serum | 102 (44) | - miR-130b-5p/miR-151a-5p/miR-206/miR-222-3p | 0.931 |
- miR-130b-5p | 0.728 | |||||
- miR-151a-5p | 0.796 | |||||
- miR-206 | 0.861 | |||||
- miR-222-3p | 0.886 | |||||
Zhang et al. [70] | 2017 | China | Plasma | 125 (50) | - miR-200c | 0.557 |
- miR-141 | 0.582 | |||||
Feliciano et al. [71] | 2020 | Spain | Serum | 80 (60) | - miR-125b/miR-29c/miR-16/miR-1260/miR-451a | 1.000/0.8167 |
188 (92) | - miR-125b/miR-29c/miR-16/miR-1260/miR-451a | 0.962/0.922 | ||||
Ibrahim et al. [72] | 2020 | Egypt | Plasma | 50 (20) | - miR-10b | 0.730 |
- miR-21-3p | 0.780 | |||||
- miR-181a | 0.700 | |||||
- miR-145 | 0.700 | |||||
Swellam et al. [73] | 2021 | Egypt | Serum | 94 (20 + 30) | - miR-27a | 0.818/0.920 |
Jang et al. [74] | 2021 | South Korea | Plasma | 136 (56) | - miR-1246 | 0.963 |
- miR-206 | 0.935 | |||||
- miR-24 | 0.965 | |||||
- miR-373 | 0.935 | |||||
- miR-1246/miR-206 | 0.988 | |||||
- miR-1246/miR-206/miR-373 | 0.991 | |||||
- miR-1246/miR-206/miR-24/miR-373 | 0.992 | |||||
Guo et al. [75] | 2020 | China | Plasma | 79 (40) | - miR-21 | 0.658 |
- miR-1273Â g-3p | 0.633 | |||||
Huang et al. [76] | 2018 | China | Serum | 235 (107) | - let-7a | 0.683 |
- miR-155 | 0.638 | |||||
- miR-574-5p | 0.891 | |||||
Ashirbkekov et al. [77] | 2020 | Kazakhstan | Plasma | 68 (33) | - miR-16-5p | 0.664 |
- miR-210-3p | 0.713 | |||||
- miR-222-3p | 0.760 | |||||
- miR-29c-3p | 0.739 | |||||
- miR-145-5p | 0.932 | |||||
- miR-191-5p | 0.904 | |||||
- miR-21 | 0.705 | |||||
- miR-145-5p/miR-191-5p | 0.984 | |||||
- miR-145-5p/miR-21-5p | 0.932 | |||||
- miR-191-5p/miR-21-5p | 0.919 | |||||
- miR-145-5p/miR-191-5p/miR-21-5p | 0.984 | |||||
Guo et al. [78] | 2018 | China | Serum | 60 (30) | - miR-1915-3p | 0.881 |
- miR-455-3p | 0.778 | |||||
Cuk et al. [79] | 2013 | Germany | Plasma | 180 (60) | - miR-127-3p | 0.650 |
- miR-148b | 0.700 | |||||
- miR-376a | 0.590 | |||||
- miR-376c | 0.590 | |||||
- miR-409-3p | 0.620 | |||||
- miR-652 | 0.750 | |||||
- miR-801 | 0.720 | |||||
- Panel of 7 miRs above | 0.810 | |||||
Raheem et al. [80] | 2019 | Iraq | Serum | 60 (30) | - miR-34a | 0.669 |
Zhu et al. [81] | 2020 | China | Serum | 120 (60) | - miR-1908-3p | 0.838 |
Ahmed Mohmmed et al. [82] | 2021 | Egypt | Serum | 80 (30) | - miR-106a | 0.947 |
Sadeghi et al. [83] | 2021 | Iran | Whole Blood | 130 (60) | - miR-145 | 0.650/0.610 |
- miR-106b-5p/miR-126-3p/miR-140-3p/miR-193a-5p/miR-10b-5p | 0.790/0.860 | |||||
Itani et al. [84] | 2021 | Lebanon | Plasma | 73 (32) | - miR-21 | 0.760 |
- miR-155 | 0.700 | |||||
- miR-23a | 0.740 | |||||
- miR-130a | 0.780 | |||||
- miR-145 | 0.810 | |||||
- miR-425-5p | 0.830 | |||||
- miR-139-5p | 0.830 | |||||
- miR-451 | 0.730 | |||||
- miR-145/miR-425-5p | 0.830 | |||||
- miR-21/miR-23a | 0.800 | |||||
- miR-21/miR-130a | 0.820 | |||||
- miR-21/miR-23a/miR-130a | 0.820 | |||||
-miR-145/miR-139-5p/mir-130a | 0.960 | |||||
- miR-145/miR-139-5p/mir-130a/miR-425-5p | 0.970 | |||||
Mahmoud et al. [85] | 2021 | Egypt | Serum | 95 (25) | - miR-185-5p | 0.838 |
- miR-301a-3p | 0.899 | |||||
Zou et al. [86] | 2022 | Multiple | Serum | 374 (197) | - miR-133a-3p/miR-497-5p/mir-24-3p/miR-125b-5p/miR-377-3p/miR-374c-5p/miR-324-5p/miR-19b-3p | 0.918 |
379 (199) | - miR-133a-3p/miR-497-5p/mir-24-3p/miR-125b-5p/miR-377-3p/miR-374c-5p/miR-324-5p/miR-19b-3p | 0.915 | ||||
325 (199)d | - miR-133a-3p/miR-497-5p/mir-24-3p/miR-125b-5p/miR-377-3p/miR-374c-5p/miR-324-5p/miR-19b-3p | 0.916 | ||||
210 (199)e | - miR-133a-3p/miR-497-5p/mir-24-3p/miR-125b-5p/miR-377-3p/miR-374c-5p/miR-324-5p/miR-19b-3p | 0.953 | ||||
Zou et al. [87] | 2021 | Singapore | Serum | 369 (100 + 196) | - miR-451a/miR-195-5p/miR-126-5p/miR-423-3p/miR-192-5p/miR-17-5p | 0.873 |
Li et al. [88] | 2022 | China | Serum | 98 (49) | - miR-9-5p | 0.852/0.937 |
- miR-17-5p | 0.706/0.652 | |||||
- miR-148a-3p | 0.866/0.875 | |||||
Shaker et al. [89] | 2021 | Egypt | Serum | 450 (150 + 120) | - miR-29 | 0.916 |
- miR-182 | 0.970 | |||||
Uyisenga et al. [90] | 2021 | Rwanda | Plasma | 45 (18) | - let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-342-3p/miR-33a-5p/miR-130a-3p/let-7i-5p/miR-328-3p/miR-29b-3p/miR-146a-5p/miR-29a-3p/miR-126-3p | 0.868 |
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-33a-5p/miR-130a-3p/miR-185-5p/let-7i-5p/miR-328-3p/miR-29b-3p/miR-146a-5p/miR-210-3p/miR-126-3p | 0.865 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-33a-5p/miR-130a-3p/let-7i-5p/miR-328-3p/miR-29b-3p/miR-210-3p/miR-126-3p | 0.865 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-342-3p/miR-33a-5p/miR-130a-3p/let-7i-5p/miR-328-3p/miR-29b-3p/miR-146a-5p/miR-210-3p/miR-126-3p | 0.865 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-33a-5p/miR-130a-3p/miR-185-5p/let-7i-5p/miR-328-3p/miR-29b-3p/miR-146a-5p/miR-29a-3p/miR-126-3p | 0.863 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-33a-5p/miR-130a-3p/let-7i-5p/miR-328-3p/miR-29b-3p/miR-146a-5p/miR-210-3p/miR-126-3p | 0.863 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-33a-5p/miR-130a-3p/let-7i-5p/miR-29b-3p/miR-146a-5p/miR-210-3p/miR-126-3p | 0.861 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-33a-5p/miR-130a-3p/miR-328-3p/miR-29a-3p/miR-126-3p | 0.859 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-33a-5p/miR-130a-3p/let-7i-5p/miR-328-3p/miR-29b-3p/miR-29a-3p/miR-126-3p | 0.859 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-33a-5p/let-7i-5p/miR-29b-3p/miR-146a-5p/miR-29a-3p/miR-126-3p | 0.859 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-32-5p/miR-130a-3p/miR-185-5p/let-7i-5p/miR-29b-3p/miR-146a-5p/miR-126-3p | 0.859 | |||||
- let-7a-5p/miR-150-5p/miR-940/miR-130a-3p/miR-328-3p/miR-29a-3p/miR-210-3p/miR-126-3p | 0.857 |