Table 1 Baseline patient characteristics
Characteristic | Overall cohort (n = 998) | Training cohort (n = 701) | Validation cohort (n = 297) | P |
|---|---|---|---|---|
N(%) | N(%) | N(%) | ||
Age, years | ||||
Median (range) | 53 (7–83) | 53 (7–83) | 54 (15–81) | 0.847 |
≤ 60 | 653 (65.4) | 460 (65.6) | 193 (65.0) | |
> 60 | 345 (34.6) | 241 (34.4) | 104 (35.0) | |
Gender | ||||
Male | 551 (55.2) | 388 (55.3) | 163 (54.9) | 0.892 |
Female | 447 (44.8) | 313 (44.7) | 134 (45.1) | |
ECOG PS | ||||
0–1 | 891 (89.3) | 623 (88.9) | 268 (90.2) | 0.525 |
≥ 2 | 107 (10.7) | 78 (11.1) | 29 (9.8) | |
Ann Arbor stage | ||||
I | 232 (23.2) | 172 (24.5) | 60 (20.2) | 0.126 |
II | 381 (38.2) | 256 (36.5) | 125 (42.1) | |
III | 156 (15.6) | 104 (14.8) | 52 (17.5) | |
IV | 229 (22.9) | 169 (24.1) | 60 (20.2) | |
Number of extranodal sites | ||||
< 2 | 755 (75.7) | 529 (75.5) | 226 (76.1) | 0.832 |
≥ 2 | 243 (24.3) | 172 (24.5) | 71 (23.9) | |
Bone marrow involvement | ||||
Yes | 56 (5.6) | 42 (6.0) | 14 (4.7) | 0.423 |
No | 942 (94.4) | 659 (94.0) | 283 (95.3) | |
Lactate dehydrogenase level | ||||
Elevated | 457 (45.8) | 330 (47.1) | 127 (42.8) | 0.211 |
Normal | 541 (54.2) | 371 (52.9) | 170 (57.2) | |
β2-microglobulin level | ||||
Elevated | 310 (31.1) | 222 (31.7) | 88 (29.6) | 0.524 |
Normal | 688 (68.9) | 479 (68.3) | 209 (70.4) | |
Serum creatinine level | ||||
Elevated | 28 (2.8) | 22 (3.1) | 6 (2.0) | 0.328 |
Normal | 970 (97.2) | 679 (96.9) | 291 (98.0) | |
IPI risk group (score) | ||||
Low (0–1) | 552 (55.3) | 390 (55.6) | 162 (54.5) | 0.177 |
Low-intermediate (2) | 203 (20.3) | 131 (18.7) | 72 (24.2) | |
High-intermediate (3) | 156 (15.6) | 116 (16.5) | 40 (13.5) | |
High (4–5) | 87 (8.7) | 64 (9.1) | 23 (7.7) | |
R-IPI risk group (score) | ||||
Very good (0) | 251 (25.2) | 174 (24.8) | 77 (25.9) | 0.320 |
Good (1–2) | 504 (50.5) | 347 (49.5) | 157 (52.9) | |
Poor (3–5) | 243 (24.3) | 180 (25.7) | 63 (21.2) | |
NCCN-IPI risk group (score) | ||||
Low (0–1) | 316 (31.7) | 221 (31.5) | 95 (32.0) | 0.525 |
Low-intermediate (2–3) | 456 (45.7) | 313 (44.7) | 143 (48.1) | |
High-intermediate (4–5) | 199 (19.9) | 146 (20.8) | 53 (17.8) | |
High (≥6) | 27 (2.7) | 21 (3.0) | 6 (2.0) | |
Hemoglobin (g/L) | ||||
≥ 120 | 780 (78.2) | 553 (78.9) | 227 (76.4) | 0.391 |
< 120 | 218 (21.8) | 148 (21.1) | 70 (23.6) | |
Albumin (g/L) | ||||
≥ 35 | 931 (93.3) | 648 (92.4) | 283 (95.3) | 0.100 |
< 35 | 67 (6.7) | 53 (7.6) | 14 (4.7) | |