Fig. 7
From: YAP1 is essential for malignant mesothelioma tumor maintenance
In vivo efficacy and biomarker modulation of K-975 in MSTO-211H and NCI-H226 xenografts: A In vivo efficacy of K-975 in MSTO-211H tumor bearing mice. B CTGF and CYR61 protein levels in tumors as determined by WES, 24 h post single K-975 administration in MSTO-211H tumor bearing mice. C In vivo efficacy of K-975 in NCI-H226 tumor bearing mice. D CYR61 protein levels in tumors by WES 24 h post single K-975 administration in NCI-H226 tumor bearing mice (n = 3). E Target occupancy ratio: TEAD1/4 covalent TEAD binding (see supplementary methods). F TEAD-dependent transcription post single K-975 administration in NCI-H226 tumor bearing mice (deR; error bars represent 95% confidence limits)