Fig. 8

A schematic representation of NOSTRIN mediated regulation of the colon cancer aggressiveness. NOSTRIN expression shows an inverse relation with the colon cancer aggressiveness and hence ectopic over-expression of NOSTRIN leads to reduction in their aggressive phenotype as evident from alterations in the EMT programme, invasive, migratory and stemness properties. Interaction of NOSTRIN with CDK1 leading to increased inhibitory CDK1 phosphorylation stalls aberrant cell cycle proliferation in colon cancer cells and presumably their stemness. Reduced Nostrin mark is a hallmark of CRC disease progression