Fig. 3

SPECT/CT analysis of the intraabdominal drug distribution pattern of ^99mTc labelled human plasma albumin. Left panel: Representative SPECT-CT scans (a, b, c) of rates in anterior-posterior maximum intensity projection (MIP) after 30 min; a = Group 3 (intraperitoneal injection without capnoperitoneum); b = Group 2 (liquid intraperitoneal injection with capnoperitoneum); c = Group 1 (USN with capnoperitoneum). Right panel (d): drug distribution represented by number of top voxels needed to exceed 30% (TVE30) of the cumulative signal in the measured volume, the higher TVE30 the higher the uniformity of drug distribution. Triangles represent individual rats (n = 5), thick horizontal lines are means, error bars represent standard deviations; Statistical significance (one-way ANOVA) is indicated by * (p < 0.05), *** (p < 0.001). 30 min = after the start of application of the radiopharmaceutical