Table 5 Univariate and multivariate Cox regression analysis of prognostic value of clinicopathological factors on tumor disease-free survival (DFS)
Variable (DFS) | Univariate cox regression analysis | Multivariate cox regression analysis | ||
|---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | |
Age at diagnosis | 0.358 | 0.370(0.127–1.074) | 0.067 | |
≦50 | 1 | |||
 > 50 | 1.461 (0.651–3.277) | |||
Tumor size | 0.015* | 3.875(1.158–12.970) | 0.028* | |
≦1 cm | 1 | |||
 > 1 cm | 3.778 (1.298–10.996) | |||
Histological grade | 0.544 | 0.811(0.201–3.276) | 0.768 | |
I/II | 1 | |||
III | 1.390 (0.479–4.037) | |||
Ki-67 index | 0.164 | 0.723(0.090–5.784) | 0.760 | |
≦30 | 1 | |||
 > 30 | 1.853 (0.778–4.414) | |||
P53 | 0.152 | 1.056(0.317–3.514) | 0.929 | |
Positive | 1 | |||
Negative | 1.841 (0.799–4.242) | |||
Basal-like marker | 0.298 | 1.042(0.197–5.512) | 0.962 | |
Negative | 1 | |||
Positive | 1.681 (0.632–4.469) | |||
Modified IHC subtype | 0.277 | 0.606(0.199–1.842) | 0.377 | |
Basal-like | 1 | |||
Luminal A | 0.381(0.110–1.316) | 0.127 | ||
Luminal B | 0.551(0.142–2.141) | 0.389 | ||
PAM50 subtype | 0.006* | 1.795(0.704–4.575) | 0.220 | |
Basal-like | 1 | |||
Luminal A | 0.290(0.082–1.026) | 0.055 | ||
Luminal B | 0.815(0.215–3.080) | 0.762 | ||
Her-2 enriched | 2.647(0.439–15.969) | 0.289 | ||
ROR | 0.001* | 2.965(1.110–7.922) | 0.030* | |
High | 1 | |||
Medium | 0.194 (0.065–0.576) | 0.003 | ||
Low | 0.112 (0.036–0.352) | 0.000 | ||
RS | 0.045* | 0.885(0.420–1.867) | 0.748 | |
High | 1 | |||
Medium | 0.306 (0.086–1.094) | 0.068 | ||
Low | 0.246 (0.081–0.743) | 0.013 | ||
TILs | 0.067 | 1.295(0.383–4.380) | 0.678 | |
Low | 1 | |||
High | 2.353 (0.943–5.873) | |||
Immune score | 0.112 | 2.458(0.870–6.945) | 0.090 | |
i-weak | 1 | |||
i-strong | 0.352 (0.244–1.159) | |||
Chemotherapy | 0.195 | 0.783(0.249(2.470) | 0.677 | |
Negative | 1 | |||
Postive | 1.688 (0.765–3.723) | |||
Radiotherapy | 0.991 | 0.811(0.270–2.430) | 0.708 | |
Negative | 1 | |||
Positive | 0.995(0.418–2.369) | |||