Fig. 2
From: The identification and validation of EphA7 hypermethylation, a novel biomarker, in cervical cancer
Promoter methylation of EphA7 is inversely correlated with gene expression in CC. a Among the 21 HumanMethylation 450 probes, 19 probes showed significantly negative expression (Pearson correlation coefficients from -0.211 to -0.522). Statistical significance was indicated in the right side (* P < 0.05,***P < 0.001) and and the promoter probes of EphA7 are highlighted in red color. b The EphA7 promoter methylation level was higher in the cancer tissues (n = 3) than in adjacent normal (n = 307) tissues according to UALCAN. c The expression of EphA7 was downregulated in cevical cancer tissues according to GEPIA based on TCGA and GTEx. d EphA7 was methylated in CaSki and SiHa cells, and unmethylated in HEK293T cells via MSP. M: methylation, U: unmethylation. Full-length gel pictures are presented in Figure. s2. e qRT–PCR showed that the expression level of EphA7 was significantly lower in CaSki and SiHa cells compared with HEK293T cells (P < 0.001)