Fig. 5

Identification of hub genes from signature genes of different subtypes. a Co-expression network of signature genes of different subtypes. The correlation between genes (expression values were log-transformed and verified to be normally distributed) were estimated by Pearson’s correlation analysis. Genes are represented by cycle nodes, whose size represents how many genes are connected to the node, and in gene networks, edges represent interactions between genes. Lollipop plots show the correlation between the expression levels of hub genes and the absolute abundance of TME cell populations in the Cancer Genome Atlas cohort b and Liver Cancer-RIKEN,JP cohort c. The size of nodes represents the power of the interrelation between genes and TME cell populations, and the shade of nodes represents the significance of the correlation