Table 1 Patient and treatment characteristics

Patient characteristics

All patients

n = 110

No pneumonitis patients

n = 91

Pneumonitis patients

n = 19

p-value

No pneumonitis vs pneumonitis (≥ grade 1)

Age

0.44

  Median (range)

68 (34–84)

67 (34–84)

69 (53–81)

Sex

0.14

  Male

82

65

17

  Female

28

26

2

Smoking history

0.10

  Current

25

19

6

  Former

45

35

10

  Never

40

37

3

Amount of smoking (pack-years)

0.024

  Median (range)

21.75 (0–190)

15.00 (0–98)

36.75 (0–190)

Types of cancer

0.40

  Head and neck cancer

23

17

6

  Gastric cancer

17

14

3

  Renal cell cancer

29

23

6

  Urothelial cancer

15

12

3

  Malignant melanoma

25

24

1

  Peritoneal mesothelioma

1

1

0

BMI (kg/m²)

0.67

  Median (range)

20.37 (14.61–36.49)

20.56 (14.63–36.49)

20.08 (14.61–32.36)

Immunotherapy

0.41

  NIVO

95

79

16

  PEM

15

12

3

ILD

0.068

  Yes

10

6

4

  No

100

85

15

Lung metastasis

0.31

  Yes

69

55

14

  No

41

36

5

Treatment line

0.66

  Median (range)

2 (1–7)

2 (1–7)

3 (1–5)

TKI

1.00

  Yes

28

23

5

  No

82

68

14

CRP (mg/dl)

0.82

  Median (range)

0.98 (0.01–11.97)

0.98 (0.01–11.97)

0.79 (0.08–10.49)

NLR

0.33

  Median (range)

3.84 (0.77–39.78)

3.79 (1.00–39.78)

4.46 (0.77–11.36)

Patient characteristics

Asymptomatic (Grade 1) pneumonitis patients

n = 7

Symptomatic (≥ grade 2) pneumonitis patients

n = 12

p-value

Asymtomatic (≤ grade 1) vs Symptomatic (≥ grade 2)

Age

0.72

  Median (range)

73 (58–81)

68.5 (53–74)

Sex

0.28

  Male

6

11

  Female

1

1

Smoking history

0.31

  Current

2

4

  Former

4

6

  Never

1

2

Amount of smoking (pack-years)

0.057

  Median (range)

36.00 (0–67.5)

40.88 (0–190)

Types of cancer

0.090

  Head and neck cancer

4

1

  Gastric cancer

2

2

  Renal cell cancer

0

6

  Urothelial cancer

0

3

  Malignant melanoma

1

0

  Peritoneal mesothelioma

0

0

BMI (kg/m²)

0.69

  Median (range)

20.16 (17.63–25.68)

20.04 (14.61–32.36)

Immunotherapy

0.21

  NIVO

7

9

  PEM

0

3

ILD

0.077

  Yes

1

3

  No

6

9

Lung metastasis

0.029

  Yes

3

11

  No

4

1

Treatment line

0.073

  Median (range)

2 (1–3)

2 (3–5)

TKI

0.18

  Yes

0

5

  No

7

7

CRP (mg/dl)

0.71

  Median (range)

0.47 (0.25–10.49)

1.16 (0.08–9.7)

NLR

0.35

  Median (range)

3.69 (0.77–11.36)

4.80 (2.35–10.42)