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Table 2 Distribution of CA125 measurements by candidate correlating factors across four quantile ranges (Q1 = [0.7300, 7.6575], Q2 = [7.6575, 11.6050], Q3 = [11.6050, 18.7750], Q4 = [18.7750, 569.37] U/ml)

From: Factors associated with serum CA125 level in women without ovarian cancer in the United States: a population-based study

Variables Q1 CA125 (N = 619) Q2 CA125 (N = 619) Q3 CA125 (N = 619) Q4 CA125 (N = 618) Overall (N = 2476)
Race/Ethnicity
 Non-Hispanic White 293 (47.3%) 313 (50.6%) 331 (53.5%) 370 (59.9%) 1307 (52.8%)
 Non-Hispanic Black 156 (25.2%) 116 (18.7%) 87 (14.1%) 89 (14.4%) 448 (18.1%)
 Mexican American 114 (18.4%) 143 (23.1%) 149 (24.1%) 112 (18.1%) 518 (20.9%)
 Other Hispanic 37 (6.0%) 19 (3.1%) 25 (4.0%) 26 (4.2%) 108 (4.4%)
 Other 19 (3.1%) 28 (4.5%) 27 (4.4%) 21 (3.4%) 95 (3.8%)
Age (years)
 Mean (SD) 52.9 (18.2) 49.2 (19.1) 46.2 (19.3) 44.1 (19.4) 48.1 (19.3)
 Median [Min, Max] 53.0 [20.0, 85.0] 49.0 [20.0, 85.0] 42.0 [20.0, 85.0] 38.0 [20.0, 85.0] 45.0 [20.0, 85.0]
BMI (kg/m2)
 Mean (SD) 29.1 (7.32) 28.8 (6.67) 28.2 (6.61) 27.7 (6.46) 28.5 (6.79)
 Median [Min, Max] 27.6 [15.8, 65.4] 27.7 [16.2, 55.4] 27.3 [17.0, 59.9] 26.5 [16.4, 61.7] 27.3 [15.8, 65.4]
Smoking history
 Non-smoker 361 (58.3%) 391 (63.2%) 384 (62.0%) 378 (61.2%) 1514 (61.1%)
 Former smoker 132 (21.3%) 113 (18.3%) 136 (22.0%) 126 (20.4%) 508 (20.5%)
 Current smoker 126 (20.4%) 115 (18.6%) 99 (16.0%) 114 (18.4%) 454 (18.3%)
Alcohol use history
 Non-drinking 198 (37.8%) 206 (38.7%) 205 (38.5%) 195 (37.7%) 805 (38.2%)
 One-two drinks per day 252 (48.1%) 243 (45.7%) 250 (47.0%) 242 (46.7%) 987 (46.8%)
 More than two drinks per day 74 (14.1%) 83 (15.6%) 77 (14.5%) 81 (15.6%) 315 (15.0%)
Daily caffeine intake (mg)
 Mean (SD) 133 (178) 125 (157) 119 (153) 124 (155) 125 (161)
 Median [Min, Max] 83.0 [0.00, 1920] 77.0 [0.00, 1140] 72.0 [0.00, 1490] 74.0 [0.00, 1190] 77.0 [0.00, 1920]
Age at menarche (years)
 ≤ 12 267 (47.8%) 266 (48.3%) 250 (44.2%) 253 (47.0%) 1036 (47.8%)
 > 12 292 (52.2%) 285 (51.7%) 315 (55.8%) 285 (53.0%) 1178 (53.2%)
Parity
 None 16 (3.2%) 11 (2.3%) 32 (6.5%) 21 (4.4%) 80 (4.1%)
 One 76 (15.4%) 86 (17.8%) 108 (21.9%) 113 (23.7%) 383 (19.7%)
 Two 143 (29.0%) 133 (27.5%) 127 (25.7%) 150 (31.5%) 553 (28.4%)
 Three 103 (20.9%) 125 (25.8%) 107 (21.7%) 105 (22.1%) 440 (22.6%)
 Four or more 155 (31.4%) 129 (26.7%) 120 (24.3%) 87 (18.3%) 492 (25.3%)
Breastfeeding history
 No 205 (43.6%) 180 (39.1%) 165 (36.7%) 161 (36.9%) 711 (39.1%)
 Yes 265 (56.4%) 280 (60.9%) 285 (63.3%) 275 (63.1%) 1106 (60.9%)
Menopause
 No 203 (35.6%) 252 (44.3%) 338 (58.6%) 364 (65.6%) 1157 (50.9%)
 Yes 368 (64.4%) 317 (55.7%) 239 (41.4%) 191 (34.4%) 1116 (49.1%)
Duration of oral contraceptive use (years)
 Less than 2 years 172 (49.3%) 154 (44.8%) 144 (41.1%) 153 (42.5%) 623 (44.4%)
 2–5 years 71 (20.3%) 72 (20.9%) 80 (22.9%) 99 (27.5%) 322 (23.0%)
 5–10 years 68 (19.5%) 72 (20.9%) 82 (23.4%) 74 (20.6%) 296 (21.1%)
 More than 10 years 38 (10.9%) 46 (13.4%) 44 (12.6%) 34 (9.4%) 162 (11.5%)
Current hormonal contraception use
 No 18 (25.7%) 15 (23.4%) 22 (31.4%) 16 (34.8%) 71 (28.4%)
 Yes 52 (74.3%) 49 (76.6%) 48 (68.6%) 30 (65.2%) 179 (71.6%)
Current hormone replacement therapy
 No 521 (84.2%) 522 (84.3%) 558 (90.1%) 570 (92.2%) 2172 (87.7%)
 Yes 98 (15.8%) 97 (15.7%) 61 (9.9%) 48 (7.8%) 304 (12.3%)
C reactive protein level (mg/dL)
 Mean (SD) 0.540 (0.888) 0.554 (0.824) 0.549 (1.030) 0.622 (1.090) 0.566 (0.962)
 Median [Min, Max] 0.290 [0.010, 14.0] 0.290 [0.010, 10.7] 0.280 [0.010, 18.5] 0.330 [0.010, 16.3] 0.300 [0.010, 18.5]
Ferritin level (ng/mL)
 Mean (SD) 93.5 (107) 79.1 (99.6) 66.7 (87.2) 67.9 (99.1) 77.0 (99.8)
 Median [Min, Max] 61.0 [3.0, 1040] 47.0 [3.0, 1230] 39.0 [3.0, 933] 33.0 [3.0, 981] 44.0 [3.0, 1230]
History of hysterectomy
 No 244 (55.5%) 237 (58.8%) 234 (70.5%) 264 (76.5%) 979 (64.4%)
 Yes 196 (44.5%) 166 (41.2%) 98 (29.5%) 81 (23.5%) 542 (35.6%)
History of oophorectomy
 No 423 (75.0%) 462 (81.5%) 505 (87.8%) 493 (89.3%) 1883 (83.4%)
 Yes 141 (25.0%) 105 (18.5%) 70 (12.2%) 59 (10.7%) 376 (16.6%)
History of salpingectomy
 No 410 (72.3%) 429 (75.9%) 448 (77.8%) 446 (80.8%) 1734 (76.7%)
 Yes 157 (27.7%) 136 (24.1%) 128 (22.2%) 106 (19.2%) 527 (23.3%)
History of endometriosis
 No 263 (90.4%) 313 (94.0%) 370 (59.8%) 367 (91.5%) 1313 (92.9%)
 Yes 28 (9.6%) 20 (6.0%) 18 (2.9%) 34 (8.5%) 100 (7.1%)
History of uterine fibroids
 No 246 (84.5%) 295 (88.9%) 345 (89.4%) 361 (89.6%) 1247 (88.3%)
 Yes 45 (15.5%) 37 (11.1%) 41 (10.6%) 42 (10.4%) 165 (11.7%)
History of osteoporosis
 No 554 (90.1%) 554 (89.8%) 562 (91.5%) 568 (92.2%) 2238 (90.9%)
 Yes 61 (9.9%) 63 (10.2%) 52 (8.5%) 48 (7.8%) 225 (9.1%)
History of osteoarthritis
 No 566 (91.4%) 557 (90.0%) 569 (91.9%) 571 (92.4%) 2264 (91.4%)
 Yes 53 (8.6%) 62 (10.0%) 50 (8.1%) 47 (7.6%) 212 (8.6%)
History of coronary artery disease
 No 593 (96.3%) 601 (97.4%) 604 (97.9%) 595 (97.4%) 2394 (97.2%)
 Yes 23 (3.7%) 16 (2.6%) 13 (2.1%) 16 (2.6%) 68 (2.8%)
History of hyperlipidemia
 No 269 (61.3%) 255 (61.3%) 270 (66.3%) 278 (68.6%) 1072 (64.3%)
 Yes 170 (38.7%) 161 (38.7%) 137 (33.7%) 127 (31.4%) 595 (35.7%)
History of non-ovarian cancer
 No 564 (91.1%) 567 (91.6%) 557 (90.3%) 573 (93.2%) 2262 (91.5%)
 Yes 55 (8.9%) 52 (8.4%) 60 (9.7%) 42 (6.8%) 209 (8.5%)
  1. SD  Standard deviation, BMI Body mass index