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Fig. 8 | BMC Cancer

Fig. 8

From: KDM3A-mediated SP1 activates PFKFB4 transcription to promote aerobic glycolysis in osteosarcoma and augment tumor development

Fig. 8

SP1 targets PFKFB4 promoter to induce its transcription. A PFKFB4 promoter sequence enriched by anti-SP1 in the ChIP-qPCR assay; B conservative transcriptional binding sequences of SP1; C PFKFB4 promoter sequences owning the binding relationship with SP1; D mutation of the PFKFB4 promoter sequence; E effect of SP1 overexpression on the transcriptional activity of the different PFKFB4 promoter sequences. Three independent experiments were performed. Differences were analyzed by the two-way ANOVA (A-E) followed by Tukey’s test. *p < 0.05

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BMC Cancer

ISSN: 1471-2407

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