Fig. 3

Response of PDOs and the xenograft model to chemotherapy. A. Dose-response curves after four days of treatment of PDOs with gemcitabine and paclitaxel. All of the experiments were carried out in triplicate, and data are represented as means ± SDs. B. Response of PDO xenograft model to gemcitabine. Four different PDOs, Sph18–02, 06, 25 and 19–22, were grafted subcutaneously in nude mice. Mice were treated with gemcitabine or vehicle twice a week at the indicated concentrations (n = 5). Results are shown as tumor volume (mm³ mean ± SD). **, P < 0.01; ns, not significant (two-tailed unpaired Student’s t test)