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Table 2 The top 10 genes detected in each cohort

From: Gene alternation of cerebrospinal fluid in patients with leptomeningeal metastases of lung adenocarcinoma using next-generation sequencing

Cohort 1

No. (%)

Cohort 2

No. (%)

No. of patients

N = 26

No. of patients

N = 8

EGFR-L858R

19 (73)

EGFR-L858R

3 (37.5)

EGFR-19del

6 (23)

EGFR-19del

3 (37.5)

EGFR-L861Q

1 (4)

EGFR-20ins

1 (12.5)

EGFR-amp

6 (23)

EGFR-L861Q

1 (12.5)

TP53

16 (62)

TP53

5 (62.5)

CDKN2A

6 (23)

EGFR-amp

4 (50)

CDK4

6 (23)

YES1

2 (25)

EGFR-T790M

4 (15)

MET

2 (25)

PIK3CG

4 (15)

FGF4

1 (12.5)

PIK3CA

3 (12)

FGF3

1 (12.5)