Table 1 Patients and tumour characteristics of the study cohort
Characteristics | No. (%) |
|---|---|
Median Age, years (range) | 53 (30–73) |
Sex | |
Female | 25 (55.6) |
Male | 20 (44.4) |
Pathology | |
Adenocarcinoma | 45 (100) |
Gene mutation status | |
EGFR | 34 (75) |
EGFR-L858R | 22 (49) |
EGFR-19Del | 9 (20) |
GFR-L861Q | 2 (4) |
EGFR-20ins | 1 (2) |
ALK | 7 (16) |
ROS1 | 3 (7) |
wild-type | 1 (2) |
Diagnosis of LM | |
Positive cytology in CSF | 25 (56) |
Typical imaging in brain MRI | 20 (44) |
Matched plasma specimen | 9 (20) |
Survival | |
Yes | 5 (11) |
No | 40 (89) |