Fig. 3

SRP9 is a co-related differentially expressed gene of DAB2IP and HSP90AA1 in CRC. a The results of related genes of DAB2IP in the colon cancer dataset "Tumor Colon—Siebersmith 355-MAS5.0-U133P2" by Gene Ontology (GO) analysis. b The results of related genes of HSP90AA1 in the colon cancer dataset "Tumor Colon—Siebersmith 355-MAS5.0-U133P2" by GO analysis. c Venn analysis of GO terms of DAB2IP and HSP90AA1 related genes gained 7 common GO terms. d Venn analysis of three common GO terms with high coincidence degree gained 71 co-related genes. e Four differentially expressed genes were screened from 71 co-related genes of DAB2IP and HSP90AA1, RPL8, RPN1, SRP9, SSR1 mRNA expression levels in human normal tissues and colorectal cancer in the TCGA database. Wilcox test was used, *P < 0.05, ** P < 0.01, ***P < 0.001 and P < 0.05 was considered statistically significant. f Verification of correlation between 4 differentially expressed genes and DAB2IP in R2 database. g Verification of correlation between 4 differentially expressed genes and HSP90AA1 in R2 database. h Real-time PCR was used to detect the expression levels of four differentially expressed genes in normal intestinal epithelial cells (NCM460 cells) and CRC cell lines (HCT116 and HT29 cells). i Protein expression levels of SRP9 in 4 pairs of CRC tissues and adjacent normal tissues from samples of CRC patients