Fig. 10
From: BARD1 mystery: tumor suppressors are cancer susceptibility genes
Schematic diagram of BARD1 dual roles in breast cancer: Diagram shows the dual roles of BARD1 gene in breast cancer. BARD1 (mainly the full length) displays a tumor suppressor role (TSR) by two mechanisms: BRCA1-dependant pathway and BRCA1-independent pathway. BARD1isoforms, epigenetic and or mutational events, or through protein-protein interaction with BLM demonstrated oncogenic role (OGR) during cancer progression associated with poor prognosis