Fig. 3

Differential gene expression profiles between the three groups of FBL mRNA levels-related groups. A heat-map was generated using transcriptomic data from the 661 primary breast tumors of TCGA series. “Low” and “high” FBL expressing tumors exhibited distinct gene expression profiles for some clusters (i.e., clusters 0, 3, 4 and 5). Blue: reduced expression level; red: increased expression level; orange: clusters with different signatures in “low” and “high” FBL expressing tumors. Gene ontology (GO) functional annotation clustering was performed using DAVID tools on the four clusters presenting difference in gene expression profiles between tumors expressing “low” or “high” FBL mRNA levels (Clusters 0, 3, 4 and 5). Enrichment of genes involved in translation was observed for the cluster 0, in glycosylation for the cluster 3 and in transcription for the clusters 4 and 5