Fig. 2

Association between FBL immunostaining and survivals in two independent breast cancer series. A In the two TMA series, FBL staining presented four different patterns based on the number of FBL dots per nucleus: “single”, “multiple”; “heterogeneous” and “no detection”. B-F Association between FBL immunostaining and OS (B, D), DFS (C), iDFS (E) and dDFS (F) was assessed using Kaplan–Meier analyses in CLB-1 (n = 389; B-C) and IGR-1 series (n = 1759; D-F). Patients harboring tumors with “no FBL detection” exhibited the poorest OS, DFS, iDFS and dDFS compared to patients with tumors that displayed FBL staining (i.e., tumors with “single” or “multiple” or “heterogeneous” FBL staining). *: P < 0.05 (E–F); scale bar: 528 µm