Table 2 Characteristics and outcome of included studies
Author | Pain and Mucositis Assessment Tool | Mucositis Status (Grade 3–4) | Study Outcome | |||
|---|---|---|---|---|---|---|
Lilleby et al. 2006 [25] | NRS NCI-CTC | Treatment | Control | P value | OC was significantly more effective than normal saline mouthwash in reducing the incidence of developing grade 3–4 OM. It also reduces the use of narcotics (P = 0.0003) and TPN (P = 0.04). The intervention did not reduce length of hospitalization; however, it improves patient's wellbeing | |
14% | 74% | 0.0005 | ||||
Gori et al. 2007 [33] | NA WHO-OTS | 47% | 53% | 0.46 | In patients receiving low dose Methotrexate chemotherapy, OC did not reduce the incidence of developing sever OM grade3-4 | |
VAS Modified version of (OMAS) | Day 10a | 1.60 ± 1.9 | 4.30 ± 5.7 | 0.042 | OC was significantly more effective than the basic oral care in reducing the incidence of OM grade 3–4. The Use of pain killers, TPN, and duration of hospital stay was also reduced | |
Day 16b | 3.70 ± 1.8 | 11.6 ± 6.8 | 0.021 | |||
2010c | 23% | 52% | < 0.05 | |||
Salvador et al. 2012 [28] | VAS WHO-OTS | Day 6 | 0.09 ± 0.12 | 0.05 ± 0.12 | 0.02 | OC was significantly more effective than the usual oral care. However, it did not reduce the duration of hospital stay (P = 0.17) or improves nutritional status |
Day 9 | 0.43 ± 0.12 | 1.14 ± 0.12 | < 0.001 | |||
Day 12 | 0.04 ± 0.12 | 0.41 ± 0.12 | 0.03 | |||
Askarifar et al. 2016 [29] | NA WHO-OTS | Day 3 | 0.31 ± 0.17 | 0.77 ± 0.43 | 0.112 | OC was significantly more effective than normal saline mouthwash in reducing the severity of OC in day 7th and 14th |
Day 7 | 1.81 ± 0.83 | 2.54 ± 0.87 | 0.031 | |||
Day 14 | 0.13 ± 0.08 | 0.92 ± 0.08 | 0.004 | |||
Marchesi et al. 2016 [30] | NRS NCI-CTC | 5.6% | 44.4% | 0.0002 | OC group presented a significant lower occurrence of both grade 3–4 OM but also reduce the need for opioids IV therapy (p = 0.001) and TPN use (P = 0.005) | |
Kamsvag et al. 2020 [32] | Children Institutional Oral Mucositis Evaluation Scale FPS (4–6 years old) NRS (≥ 7 years old) WHO-OTS | 58% | 48% | 0.43 | OC did not reduce the incidence of sever OM and use of pain killers (P = 0.34) and TPN (P = 0.35) | |
Lu et al. 2020 [31] | NA NCI-CTC | 24% | 39% | 0.012 | Both arm A and B were associated with a reduction on the incidence and duration of OM compared to arm D | |