Questionnaire item | Study population n = 158 | Reference populationa n = 4910 | p-value | Absolute difference between means |
---|---|---|---|---|
QLQ-C30, mean ± SD | ||||
Global health status1 | 55.9 ± 24.7 | 76.4 ± 22.8 | < 0.001 | 20.5c |
Summary score2 | 73.1 ± 18.6 | No reference data available | - | - |
Function* | ||||
Physical function3 | 76.9 ± 21.2 | 88.0 ± 18.3 | < 0.001 | 11.1c |
Role function4 | 65.4 ± 36.1 | 82.2 ± 23.9 | < 0.001 | 16.8c |
Emotional function5 | 69.3 ± 24.8 | 85.8 ± 18.7 | < 0.001 | 16.5c |
Cognitive function6 | 84.6 ± 21.4 | 88.1 ± 16.9 | 0.011 | 3.5 |
Social function7 | 74.9 ± 28.5 | 91.2 ± 19.0 | < 0.001 | 16.3c |
Symptom** | ||||
Fatigue8 | 40.2 ± 27.9 | 19.1 ± 21.7 | < 0.001 | 21.1c |
Nausea and vomiting9 | 20.2 ± 26.9 | 2.6 ± 9.3 | < 0.001 | 17.6c |
Pain10 | 27.8 ± 31.7 | 18.9 ± 25.7 | < 0.001 | 8.9 |
Dyspnoea11 | 28.8 ± 31.0 | 16.3 ± 24.3 | < 0.001 | 12.5c |
Insomnia12 | 35.5 ± 33.3 | 17.5 ± 25.9 | < 0.001 | 18.0c |
Appetite loss13 | 42.1 ± 40.7 | 3.3 ± 12.8 | < 0.001 | 38.8c |
Constipation14 | 24.1 ± 31.8 | 5.4 ± 6.1 | < 0.001 | 18.7c |
Diarrhoea15 | 11.0 ± 20.2 | 5.6 ± 15.9 | < 0.001 | 5.4 |
Financial difficulties16 | 7.5 ± 19.8 | 4.4 ± 16.2 | 0.019 | 3.1 |
QLQ-OG25**, mean ± SD | Reference populationb | |||
Dysphagia17 | 33.3 ± 33.2 | 0.8 ± 5.5 | < 0.001 | 32.5d |
Eating restrictions18 | 45.8 ± 35.1 | 2.9 ± 9.9 | < 0.001 | 42.9d |
Reflux19 | 17.3 ± 26.0 | 6.7 ± 15.4 | < 0.001 | 10.6d |
Odynophagia20 | 35.6 ± 33.7 | 1.5 ± 8.23 | < 0.001 | 34.1d |
Pain and discomfort21 | 27.9 ± 33.9 | 7.6 ± 16.9 | < 0.001 | 20.3d |
Anxiety22 | 65.1 ± 28.4 | No reference data available | - | - |
Eating with others23 | 30.2 ± 39.1 | 1.3 ± 8.9 | < 0.001 | 28.9d |
Dry mouth24 | 26.7 ± 32.7 | 11.5 ± 23.0 | < 0.001 | 15.2d |
Sense of taste25 | 15.6 ± 27.1 | 2.6 ± 12.5 | < 0.001 | 13.0d |
Body image26 | 24.5 ± 33.2 | No reference data available | - | - |
Saliva27 | 14.0 ± 26.3 | 1.3 ± 9.2 | < 0.001 | 12.7d |
Choking28 | 20.7 ± 29.8 | 3.7 ± 13.1 | < 0.001 | 17.0d |
Cough29 | 24.0 ± 27.8 | 13.7 ± 23.6 | < 0.001 | 10.3d |
Speech30 | 8.2 ± 20.5 | 2.2 ± 11.0 | < 0.001 | 6.0d |
Weight loss31 | 28.4 ± 34.9 | 1.8 ± 10.5 | < 0.001 | 26.6d |
Hair loss32 | 11.7 ± 27.1 | No reference data available | - | - |