Fig. 5
From: AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer
AXL regulates NRG1. A The expression levels of NRG1 in HN30-Vector, HN30-AXL PCI37A-Vector and PCI37A-AXL cells were determined by qPCR and immunoblot analysis. α-Tubulin was used as a loading control. Mean values, SEs, and statistical analyses are representative of three independent experiments. N = 2–4. B Whole cell lysates were harvested from HNSCC PDX tumors and fractionated via SDS-PAGE, followed by an immunoblot for indicated proteins. GAPDH was used as a loading control. The densitometry values represent the mean ratios of NRG1/GAPDH from two independent experiments. Error bars: SEM (*P < 0.05, Mann–Whitney test)