Table 3 Analysis results for cancer-specific and overall survival in endometrial cancer patients with compared to without diabetes
| Â | No. of included studies | No. of EC patients | Pooled estimate (95% CI) | I-Squared (%) | Pheterogeneity value |
|---|---|---|---|---|---|
Endometrial cancer-specific survival | |||||
 Main analysis | 17 | 35,814 | 1.15 (1.00–1.32) | 62.2 |  < 0.01 |
 Multivariate analysis | 15 | 35,172 | 1.17 (1.00–1.35) | 66.3 |  < 0.01 |
 Restricting to studies that reported a HR | 15 | 35,274 | 1.16 (1.07–1.33) | 59.8 |  < 0.01 |
 Studies with a quality score of ≤ 7 | 13 | 11,762 | 1.17 (0.97–1.42) | 61.2 |  < 0.01 |
 Studies with a quality score of > 7 | 4 | 24,052 | 1.23 (1.07–1.42) | 6.4 | 0.36 |
 Studies with a follow-up of < 5 years a | 4 | 4,275 | 1.27 (0.89–1.82) | 60.7 | 0.05 |
 Studies with a follow-up of ≥ 5 years a | 9 | 7,605 | 1.15 (0.88–1.49) | 65.1 |  < 0.01 |
 Population-based studies | 9 | 26,945 | 1.24 (1.05–1.47) | 61.0 |  < 0.01 |
 Institution-based studies | 7 | 8,742 | 1.04 (0.79–1.37) | 59.6 | 0.02 |
 Self-reported diabetes | 7 | 7,480 | 1.32 (0.87–1.99) | 69.7 |  < 0.01 |
 Medical record reported diabetes | 10 | 28,334 | 1.13 (0.98–1.30) | 57.5 | 0.01 |
 Endometrioid histology | 4 | 4,4453 | 1.20 (0.84–1.72) | 41.6 | 0.16 |
 Non-endometrioid histology | 4 | 2,079 | 1.00 (0.81–1.23) | 0.0 | 0.47 |
 Restricted to white women | 2 | 23,099 | 1.26 (1.22–1.31) | 0.0 | 0.62 |
 Restricted to black women | 2 | 1,229 | 0.92 (0.71–1.20) | 0.0 | 0.40 |
 Adjusted for BMI b | 6 | 6,887 | 0.94 (0.72–1.23) | 40.6 | 0.01 |
 Undergone surgery | 6 | 7,983 | 1.44 (0.93–2.22) | 75.0 |  < 0.01 |
Overall survival | |||||
 Main analysis | 24 | 26,352 | 1.42 (1.31–1.54) | 46.3 | 0.01 |
 Multivariate analysis | 20 | 25,563 | 1.43 (1.31–1.56) | 54.3 |  < 0.01 |
 Univariate analysis | 9 | 5,998 | 1.33 (1.21–1.46) | 0.0 | 0.79 |
 Studies with a quality score of ≤ 7 | 21 | 23,787 | 1.41 (1.29–1.54) | 47.1 | 0.01 |
 Studies with a quality score of > 7 | 3 | 2,565 | 1.45 (1.12–1.88) | 38.4 | 0.20 |
 Studies with a follow-up of < 5 years a | 6 | 15,136 | 1.28 (1.21–1.37) | 0.0 | 0.48 |
 Studies with a follow-up of ≥ 5 years a | 8 | 4,767 | 1.65 (1.32–2.06) | 76.8 |  < 0.01 |
 Population-based studies | 9 | 19,158 | 1.43 (1.27–1.61) | 72.9 |  < 0.01 |
 Institution-based studies | 15 | 7,194 | 1.43 (1.28–1.61) | 0.0 | 0.70 |
 Self-reported diabetes | 5 | 3,371 | 1.99 (1.61–2.46) | 32.8 | 0.20 |
 Medical record reported diabetes | 15 | 21,240 | 1.28 (1.22–1.34) | 0.0 | 0.92 |
 Endometrioid histology | 5 | 3,196 | 1.63 (1.18–2.25) | 41.2 | 0.15 |
 Restricted to white women | 2 | 11,966 | 1.35 (1.09–1.65) | 41.9 | 0.19 |
 Restricted to black women | 2 | 1,229 | 1.27 (1.08–1.50) | 0.0 | 0.63 |
 Adjusted for BMI | 7 | 5,374 | 1.52 (1.22–1.90) | 59.6 | 0.02 |
 Overweight and obese patients (≥ 25 kg/m2 or ≥ 30 kg/m2) | 2 | 824 | 1.76 (1.19–2.61) | 0.0 | 0.93 |
 Undergone surgery | 11 | 5,209 | 1.57 (1.28–1.93) | 62.7 |  < 0.01 |