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Table 3 Analysis results for cancer-specific and overall survival in endometrial cancer patients with compared to without diabetes

From: Survival outcomes in endometrial cancer patients according to diabetes: a systematic review and meta-analysis

  No. of included studies No. of EC patients Pooled estimate (95% CI) I-Squared (%) Pheterogeneity value
Endometrial cancer-specific survival
 Main analysis 17 35,814 1.15 (1.00–1.32) 62.2  < 0.01
 Multivariate analysis 15 35,172 1.17 (1.00–1.35) 66.3  < 0.01
 Restricting to studies that reported a HR 15 35,274 1.16 (1.07–1.33) 59.8  < 0.01
 Studies with a quality score of ≤ 7 13 11,762 1.17 (0.97–1.42) 61.2  < 0.01
 Studies with a quality score of > 7 4 24,052 1.23 (1.07–1.42) 6.4 0.36
 Studies with a follow-up of < 5 years a 4 4,275 1.27 (0.89–1.82) 60.7 0.05
 Studies with a follow-up of ≥ 5 years a 9 7,605 1.15 (0.88–1.49) 65.1  < 0.01
 Population-based studies 9 26,945 1.24 (1.05–1.47) 61.0  < 0.01
 Institution-based studies 7 8,742 1.04 (0.79–1.37) 59.6 0.02
 Self-reported diabetes 7 7,480 1.32 (0.87–1.99) 69.7  < 0.01
 Medical record reported diabetes 10 28,334 1.13 (0.98–1.30) 57.5 0.01
 Endometrioid histology 4 4,4453 1.20 (0.84–1.72) 41.6 0.16
 Non-endometrioid histology 4 2,079 1.00 (0.81–1.23) 0.0 0.47
 Restricted to white women 2 23,099 1.26 (1.22–1.31) 0.0 0.62
 Restricted to black women 2 1,229 0.92 (0.71–1.20) 0.0 0.40
 Adjusted for BMI b 6 6,887 0.94 (0.72–1.23) 40.6 0.01
 Undergone surgery 6 7,983 1.44 (0.93–2.22) 75.0  < 0.01
Overall survival
 Main analysis 24 26,352 1.42 (1.31–1.54) 46.3 0.01
 Multivariate analysis 20 25,563 1.43 (1.31–1.56) 54.3  < 0.01
 Univariate analysis 9 5,998 1.33 (1.21–1.46) 0.0 0.79
 Studies with a quality score of ≤ 7 21 23,787 1.41 (1.29–1.54) 47.1 0.01
 Studies with a quality score of > 7 3 2,565 1.45 (1.12–1.88) 38.4 0.20
 Studies with a follow-up of < 5 years a 6 15,136 1.28 (1.21–1.37) 0.0 0.48
 Studies with a follow-up of ≥ 5 years a 8 4,767 1.65 (1.32–2.06) 76.8  < 0.01
 Population-based studies 9 19,158 1.43 (1.27–1.61) 72.9  < 0.01
 Institution-based studies 15 7,194 1.43 (1.28–1.61) 0.0 0.70
 Self-reported diabetes 5 3,371 1.99 (1.61–2.46) 32.8 0.20
 Medical record reported diabetes 15 21,240 1.28 (1.22–1.34) 0.0 0.92
 Endometrioid histology 5 3,196 1.63 (1.18–2.25) 41.2 0.15
 Restricted to white women 2 11,966 1.35 (1.09–1.65) 41.9 0.19
 Restricted to black women 2 1,229 1.27 (1.08–1.50) 0.0 0.63
 Adjusted for BMI 7 5,374 1.52 (1.22–1.90) 59.6 0.02
 Overweight and obese patients (≥ 25 kg/m2 or ≥ 30 kg/m2) 2 824 1.76 (1.19–2.61) 0.0 0.93
 Undergone surgery 11 5,209 1.57 (1.28–1.93) 62.7  < 0.01
  1. aOnly included studies which reported a mean or median follow-up
  2. bSung et al. adjusted for obesity
  3. EC Endometrial cancer, CI Confidence Interval, HR Hazard Ratio