|
Endometrial cancer-specific survival
|
|
Main analysis
|
17
|
35,814
|
1.15 (1.00–1.32)
|
62.2
|
< 0.01
|
|
Multivariate analysis
|
15
|
35,172
|
1.17 (1.00–1.35)
|
66.3
|
< 0.01
|
|
Restricting to studies that reported a HR
|
15
|
35,274
|
1.16 (1.07–1.33)
|
59.8
|
< 0.01
|
|
Studies with a quality score of ≤ 7
|
13
|
11,762
|
1.17 (0.97–1.42)
|
61.2
|
< 0.01
|
|
Studies with a quality score of > 7
|
4
|
24,052
|
1.23 (1.07–1.42)
|
6.4
|
0.36
|
|
Studies with a follow-up of < 5 years a
|
4
|
4,275
|
1.27 (0.89–1.82)
|
60.7
|
0.05
|
|
Studies with a follow-up of ≥ 5 years a
|
9
|
7,605
|
1.15 (0.88–1.49)
|
65.1
|
< 0.01
|
|
Population-based studies
|
9
|
26,945
|
1.24 (1.05–1.47)
|
61.0
|
< 0.01
|
|
Institution-based studies
|
7
|
8,742
|
1.04 (0.79–1.37)
|
59.6
|
0.02
|
|
Self-reported diabetes
|
7
|
7,480
|
1.32 (0.87–1.99)
|
69.7
|
< 0.01
|
|
Medical record reported diabetes
|
10
|
28,334
|
1.13 (0.98–1.30)
|
57.5
|
0.01
|
|
Endometrioid histology
|
4
|
4,4453
|
1.20 (0.84–1.72)
|
41.6
|
0.16
|
|
Non-endometrioid histology
|
4
|
2,079
|
1.00 (0.81–1.23)
|
0.0
|
0.47
|
|
Restricted to white women
|
2
|
23,099
|
1.26 (1.22–1.31)
|
0.0
|
0.62
|
|
Restricted to black women
|
2
|
1,229
|
0.92 (0.71–1.20)
|
0.0
|
0.40
|
|
Adjusted for BMI b
|
6
|
6,887
|
0.94 (0.72–1.23)
|
40.6
|
0.01
|
|
Undergone surgery
|
6
|
7,983
|
1.44 (0.93–2.22)
|
75.0
|
< 0.01
|
|
Overall survival
|
|
Main analysis
|
24
|
26,352
|
1.42 (1.31–1.54)
|
46.3
|
0.01
|
|
Multivariate analysis
|
20
|
25,563
|
1.43 (1.31–1.56)
|
54.3
|
< 0.01
|
|
Univariate analysis
|
9
|
5,998
|
1.33 (1.21–1.46)
|
0.0
|
0.79
|
|
Studies with a quality score of ≤ 7
|
21
|
23,787
|
1.41 (1.29–1.54)
|
47.1
|
0.01
|
|
Studies with a quality score of > 7
|
3
|
2,565
|
1.45 (1.12–1.88)
|
38.4
|
0.20
|
|
Studies with a follow-up of < 5 years a
|
6
|
15,136
|
1.28 (1.21–1.37)
|
0.0
|
0.48
|
|
Studies with a follow-up of ≥ 5 years a
|
8
|
4,767
|
1.65 (1.32–2.06)
|
76.8
|
< 0.01
|
|
Population-based studies
|
9
|
19,158
|
1.43 (1.27–1.61)
|
72.9
|
< 0.01
|
|
Institution-based studies
|
15
|
7,194
|
1.43 (1.28–1.61)
|
0.0
|
0.70
|
|
Self-reported diabetes
|
5
|
3,371
|
1.99 (1.61–2.46)
|
32.8
|
0.20
|
|
Medical record reported diabetes
|
15
|
21,240
|
1.28 (1.22–1.34)
|
0.0
|
0.92
|
|
Endometrioid histology
|
5
|
3,196
|
1.63 (1.18–2.25)
|
41.2
|
0.15
|
|
Restricted to white women
|
2
|
11,966
|
1.35 (1.09–1.65)
|
41.9
|
0.19
|
|
Restricted to black women
|
2
|
1,229
|
1.27 (1.08–1.50)
|
0.0
|
0.63
|
|
Adjusted for BMI
|
7
|
5,374
|
1.52 (1.22–1.90)
|
59.6
|
0.02
|
|
Overweight and obese patients (≥ 25 kg/m2 or ≥ 30 kg/m2)
|
2
|
824
|
1.76 (1.19–2.61)
|
0.0
|
0.93
|
|
Undergone surgery
|
11
|
5,209
|
1.57 (1.28–1.93)
|
62.7
|
< 0.01
|
