Fig. 3
From: OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis
OLA1 expression is associated with increased CA9, necrosis and proliferation in HCT116 and Lovo xenografts. Representative immunohistochemical images of HCT116 (A) and Lovo (B), control and OLA1-KO xenografts. The expression of OLA1, CA9, HIF1, Ki67, and the fraction of necrosis between the control and OLA1-KO groups were substantially different. The expression staining of OLA1, CA9, HIF-1, and Ki-67 were depicted in dark brown. The dark pink stain in H&E indicates living tissue, while the light pink stain indicates necrosis. SD is represented by the error bars. Necrosis is indicated by the letter N. Positive staining is indicated by red arrows