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Table 4 Hazard ratios and 95% confidence intervals for individual vegetable and fruit items and Cancer of Unknown Primary risk in the Netherlands Cohort Study a

From: Vegetable and fruit consumption and cancer of unknown primary risk: results from the Netherlands cohort study on diet and cancer

 

Follow-up time (years)

Cancer of Unknown Primary cases (n = 867)

Age- and sex- adjusted

Multivariable adjusted b

HR

95% CI

HR

95% CI

Vegetable item (25 g per day increments)

 String/French beans

20.3

1.02

(0.90-1.15)

1.01

(0.89-1.15)

 Cauliflower

20.3

0.95

(0.80-1.14)

0.95

(0.79-1.15)

 Lettuce

20.3

0.75

(0.57-1.01)

0.83

(0.62-1.13)

 Carrots, cookedc

0-10

0.95

(0.68-1.31)

1.03

(0.75-1.41)

 

10-20.3

0.73

(0.55-0.97)

0.78

(0.59-1.03)

 Endive, cookedc

0-10

0.99

(0.75-1.31)

1.01

(0.76-1.33)

 

10-20.3

0.83

(0.66-1.06)

0.85

(0.67-1.08)

 Brussels sprouts

20.3

1.04

(0.81-1.35)

1.06

(0.81-1.37)

 Sauerkraut

20.3

1.07

(0.75-1.52)

1.12

(0.78-1.62)

 Tomatoes

20.3

0.96

(0.87-1.06)

0.98

(0.89-1.08)

 Onion

20.3

0.99

(0.90-1.10)

1.02

(0.91-1.13)

 Spinach

20.3

0.99

(0.80-1.22)

1.02

(0.82-1.27)

 Beetrootc

0-10

0.91

(0.64-1.28)

0.99

(0.69-1.41)

 

10-20.3

0.60

(0.42-0.85)

0.64

(0.44-0.92)

 Kale

20.3

0.86

(0.49-1.52)

0.93

(0.53-1.63)

Fruit item (25 g per day increments)

 Apples and pearsc

0-10

0.95

(0.91-0.99)

0.97

(0.94-1.01)

 

10-20.3

0.98

(0.95-1.01)

0.99

(0.96-1.03)

 Strawberries

20.3

0.99

(0.77-1.27)

1.06

(0.83-1.36)

 Oranges and fresh orange juice

20.3

1.01

(0.97-1.04)

1.03

(0.99-1.07)

  1. aThe total person time at risk in the subcohort was 67,810 years
  2. bAnalyses were adjusted for age at baseline (years), sex, cigarette smoking status (never/ever), frequency (continuous; centered), duration (continuous; centered), and total vegetable and fruit consumption (grams per day; continuous). All items were assessed while additionally using cigarette smoking status (never/ever), and duration (continuous; centered) as time-varying covariates
  3. cThe proportional hazards assumption was violated for the exposure variable in this analysis, consequently these associations were splitted based on follow-up time