Clinicopathological characteristics | Total: n = 386 (%) | No ACT: n = 263 (%) | ACT: n = 123 (%) | P-value |
---|---|---|---|---|
Sex | ||||
Male | 203 (52.6) | 127 (48.3) | 76 (61.8) | 0.016 |
Female | 183 (47.4) | 136 (51.7) | 47 (38.2) | |
Age, median (range)(years) | 73.1 (28,5 – 94.0) | 76.3 (28.5 – 94.0) | 64.9 (34.5 – 83.3) | < 0.001 |
Right sided tumour | 173 (45.1) | 117 (44.5) | 56 (45.5) | 0.91 |
Diameter, median (range)(mm) | 40.0 (10.0 – 130.0) | 40.0 (10.0 – 130.0) | 35.0 (10.0 – 100.0) | 0.009 |
Histological grade | ||||
Well | 24 (6.2) | 17 (6.5) | 7 (5.7) | 0.93 |
Moderate | 302 (78.2) | 206 (78.3) | 96 (78.0) | |
Poor | 60 (15.5) | 40 (15.2) | 20 (16.3) | |
Stage | ||||
II (= N0) | 226 (58.5) | 192 (73.0) | 34 (27.6) | < 0.001 |
III (= N+) | 160 (41.5) | 71 (27.0) | 89 (72.4) | |
Tumour stage | ||||
T1 | 4 (1.0) | 2 (0.8) | 2 (1.6) | 0.022 |
T2 | 19 (4.9) | 8 (3.0) | 11 (8.9) | |
T3 | 325 (84.2) | 231 (87.8) | 94 (76.4) | |
T4 | 38 (9.8) | 22 (8.4) | 16 (13.0) | |
Nodal stage (stage III) | ||||
N1 | 110 (28.5) | 54 (20.5) | 56 (45.5) | < 0.001 |
N2 | 49 (12.7) | 17 (6.5) | 32 (26.0) | |
Mucinous differentiation | 82 (21.2) | 64 (24.3) | 18 (14.6) | 0.033 |
Isolated tumour deposits (ITD) | 50 (13.0) | 24 (9.1) | 26 (21.1) | 0.001 |
MSI-status | ||||
MSI | 65 (16.8) | 47 (21.4) | 18 (16.1) | 0.31 |
MSS | 332 (86.0) | 173 (78.6) | 94 (83.9) | |
Ulceration | 297 (76.9) | 196 (74.5) | 101 (82.1) | 0.12 |
Lymphovascular invasion (LVI) | 78 (20.2) | 44 (16.7) | 34 (27.6) | 0.015 |
Emergency surgery | 51 (13.2) | 35 (13.3) | 16 (13.0) | 1.0 |
Perforation | ||||
Before surgery | 16 (4.1) | 12 (4.6) | 4 (3.3) | 0.38 |
During surgery | 5 (1.3) | 4 (1.5) | 1 (0.8) | |
After surgery | 10 (2.7) | 9 (3.4) | 1 (0.8) | |
Tumour spill | 12 (3.1) | 9 (3.4) | 3 (2.4) | 0.76 |
Recurrence | 127 (32.9) | 77 (29.3) | 50 (40.7) | 0.036 |
CRC mortality | 101 (26.2) | 64 (24.3) | 37 (30.1) | 0.26 |
Overall mortality | 177 (45.9) | 133 (50.6) | 44 (35.8) | 0.008 |
Follow-up (median, range) (months) | 57,2 (3 – 148) | 57.1 (3 – 148) | 57.5 (3 – 127) | 0.73 |