Skip to main content

Table 1 Baseline parameters of this cohort of 386 stage II and III colon cancer patients, stratified for ACT (P-values for differences in baseline between ACT treated and untreated patients were calculated using chi-square, or Mann Whitney U when appropriate)

From: KCNQ1 and lymphovascular invasion are key features in a prognostic classifier for stage II and III colon cancer

Clinicopathological characteristics Total: n = 386 (%) No ACT: n = 263 (%) ACT: n = 123 (%) P-value
Sex
 Male 203 (52.6) 127 (48.3) 76 (61.8) 0.016
 Female 183 (47.4) 136 (51.7) 47 (38.2)
Age, median (range)(years) 73.1 (28,5 – 94.0) 76.3 (28.5 – 94.0) 64.9 (34.5 – 83.3)  < 0.001
Right sided tumour 173 (45.1) 117 (44.5) 56 (45.5) 0.91
Diameter, median (range)(mm) 40.0 (10.0 – 130.0) 40.0 (10.0 – 130.0) 35.0 (10.0 – 100.0) 0.009
Histological grade
 Well 24 (6.2) 17 (6.5) 7 (5.7) 0.93
 Moderate 302 (78.2) 206 (78.3) 96 (78.0)
 Poor 60 (15.5) 40 (15.2) 20 (16.3)
Stage
 II (= N0) 226 (58.5) 192 (73.0) 34 (27.6)  < 0.001
 III (= N+) 160 (41.5) 71 (27.0) 89 (72.4)
Tumour stage
 T1 4 (1.0) 2 (0.8) 2 (1.6) 0.022
 T2 19 (4.9) 8 (3.0) 11 (8.9)
 T3 325 (84.2) 231 (87.8) 94 (76.4)
 T4 38 (9.8) 22 (8.4) 16 (13.0)
Nodal stage (stage III)
 N1 110 (28.5) 54 (20.5) 56 (45.5)  < 0.001
 N2 49 (12.7) 17 (6.5) 32 (26.0)
Mucinous differentiation 82 (21.2) 64 (24.3) 18 (14.6) 0.033
Isolated tumour deposits (ITD) 50 (13.0) 24 (9.1) 26 (21.1) 0.001
MSI-status
 MSI 65 (16.8) 47 (21.4) 18 (16.1) 0.31
 MSS 332 (86.0) 173 (78.6) 94 (83.9)
Ulceration 297 (76.9) 196 (74.5) 101 (82.1) 0.12
Lymphovascular invasion (LVI) 78 (20.2) 44 (16.7) 34 (27.6) 0.015
Emergency surgery 51 (13.2) 35 (13.3) 16 (13.0) 1.0
Perforation
 Before surgery 16 (4.1) 12 (4.6) 4 (3.3) 0.38
 During surgery 5 (1.3) 4 (1.5) 1 (0.8)
 After surgery 10 (2.7) 9 (3.4) 1 (0.8)
Tumour spill 12 (3.1) 9 (3.4) 3 (2.4) 0.76
Recurrence 127 (32.9) 77 (29.3) 50 (40.7) 0.036
CRC mortality 101 (26.2) 64 (24.3) 37 (30.1) 0.26
Overall mortality 177 (45.9) 133 (50.6) 44 (35.8) 0.008
Follow-up (median, range) (months) 57,2 (3 – 148) 57.1 (3 – 148) 57.5 (3 – 127) 0.73