Study | Country | study design | Cases vs Controls | Specimen | Stage | Status Controls | Detection Method | markers | SEN% | SPE% | AUC | P Value | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  | Number | Age | Male (%) |  |  |  |  |  |  |  |  |  |
 |  |  |  |  |  |  |  |  |  | miRNA |  |  |  |  |
Xu, 2017 [46] | USA | Case–control | 15/15 | 67/48 | 53/27 | Plasma | I-IIA | HC | qPCR | miR-196a | 87e | 73e | 0.81 |  < 0.001 |
miR-1246 | 67e | 80e | 0.73 | 0.019 | ||||||||||
miR-196b | 67e | 80e | 0.71 | 0.033 | ||||||||||
Lai, 2017 [45] | USA | Case–control | 29/6 | 67/NA | 52/NA | Plasma | I-IV | HC | qPCR | miR-10b | 100 | 100 | 1.00 |  < 0.001 |
miR-21 | 100 | 100 | 1.00 |  < 0.001 | ||||||||||
miR-30c | 100 | 100 | 1.00 |  < 0.001 | ||||||||||
miR-106b | 62 | 100 | 0.85 | 0.007* | ||||||||||
miR-20a | 83 | 100 | 0.95 |  < 0.001 | ||||||||||
miR-181a | 100 | 100 | 1.00 |  < 0.001 | ||||||||||
miR-let7a | 100 | 100 | 1.00 |  < 0.001 | ||||||||||
miR-122 | 93 | 100 | 0.99 |  < 0.001 | ||||||||||
Goto, 2018 [84] | Japan | Case–control | 32/22 | 64/58 | 53/64 | Serum | I-IV | HC | qPCR | miR-191 | 72 | 84 | 0.79 | 0.001 |
miR-21 | 81 | 81 | 0.83 |  < 0.001 | ||||||||||
miR-451a | 66 | 86 | 0.76 | 0.002 | ||||||||||
9/22 | NA/58 | NA/64 | Serum | I-IIA | HC | qPCR | miR-191 | 67 | 84 | 0.75 | 0.032 | |||
miR-21 | 67 | 81 | 0.74 | 0.004 | ||||||||||
miR-451a | 67 | 86 | 0.74 | 0.044 | ||||||||||
23/22 | NA/58 | NA/64 | Serum | IIB-IV | HC | qPCR | miR-191 | 79 | 79 | 0.80 | 0.001 | |||
miR-21 | 86 | 81 | 0.86 |  < 0.001 | ||||||||||
miR-451a | 70 | 81 | 0.77 | 0.002 | ||||||||||
Zhou, 2020 [62] | China | Case–control | 30/10 | 60/58 | / | Plasma | I-IV | NCb | 3D mircrofluidic chip | miR-451a | 81e | 100e | 0.93 | / |
miR-21 | 87e | 100e | 0.94 | / | ||||||||||
miR-10b | 79e | 99e | 0.88 | / | ||||||||||
miRNA | Â | Â | Â | Â | ||||||||||
Reese, 2020 [31] | Germany | Case–control | 56/22 | NA/68 | 64/50 | Serum | II-IV | HC | qPCR | miR-200b | 67e | 76e | 0.79 | 0.0001 |
qPCR | miR-200c | 51e | 90e | 0.67 | 0.0239 | |||||||||
56/11 | NA/62 | 64/55 | Serum | II-IV | CP | qPCR | miR-200b | 63e | 86e | 0.77 | 0.0047 | |||
56/33 | Â | 64/52 | Serum | II-IV | NCc | qPCR | miR-200b | 85e | 63e | 0.77 | 0.005 | |||
56/22 | NA/68 | 64/50 | Â | II-IV | HC | qPCR | miR-200b | 63e | 68e | 0.69 | 0.0077 | |||
Wu, 2020 [61] | China | Case–control | 30/10 | 62/51 | 60/80 | serum | 0-IV | CP | qPCR | miR-21 | 80 | 90 | 0.87 | / |
miR-210 | 83 | 90 | 0.82 | / | ||||||||||
Pu, 2020 [25] | China | Case–control | 36/65 | / | / | Plasma | I-IV | HC | cationic lipoplex nanoparticle | miR-21 | 53e | 98e | 0.72 | 0.0003 |
miR-10b | 42e | 100e | 0.65 | 0.0105 | ||||||||||
Flammang, 2020 [59]a | Germany | Case–control | 44/12 | / | / | serum | II-IV | HC | qPCR | miR-192-5p | 64e | 99e | 0.83 | 0.0004 |
Wang, 2021 [64] | China | Case–control | 17/12 | / | / | serum | / | PBT | qPCR | miRNA-1226-3p | 75e | 66e | 0.74 / | |
Xiao, 2021 [70] | China | Case–control | 10/10 | / | / | Plasma |  | HC | PNA-functionalized nanochannel sensor | miR-10b | / | / | 0.99 | / |
Shao, 2021 [74] | China | Case–control | 63/22 | 60/50 | 56/41 | serum | I-IV | HC | qPCR | miR-483-3p | 82e | 56e | 0.69 | / |
Wang L, 2021 [72] | China | Case–control | 62/53 | / | / | plasma |  | HC | qPCR | miR-19b-3p | 85 | 91 | 0.94 |  < 0.001 |
62/23 | / | / | CP |  | 81 | 87 | 0.90 |  < 0.001 | ||||||
62/30 | / | / | OPT |  | 94 | 63 | 0.81 |  < 0.001 | ||||||
Chen, 2022 [68] | China | Case–control | 191/90 | 62/57 | 57/52 | serum | I-IV |  | HC PBD | miR-451a | 80 | 87 | 0.90 | / |
191/95 | 62/59 | 57/58 | Â | 71 | 89 | 0.86 | / | |||||||
LncRNA | Â | Â | Â | Â | ||||||||||
Takahashi, 2019 [80] | Japan | Case–control | 20/43 | 72/71 | 40/42 | Serum | II-IV | NCd | dPCR | HULC | 80 | 92 | 0.92 | / |
20/21 | 72/72 | 40/36 | Serum | II-IV | HC | dPCR | HULC | 80 | 95 | 0.94 | / | |||
20/22 | 72/70 | 40/48 | Serum | II-IV | IPMN | dPCR | HULC | 85 | 83 | 0.91 | / | |||
Guo, 2021 [78]a | China | Case–control | 27/15 | 58/44 | 63/60 | plasma | IB-IV | CP | small RNA sequencing | miR-95-3p | 92e | 94e | 0.91 |  |
miR-199b-3p | / | / | 0.90 | Â | ||||||||||
miR-3158-3p | / | / | 0.90 | Â | ||||||||||
miR-199a-3p | / | / | 0.89 | Â | ||||||||||
miR-4732-3p | / | / | 0.88 | Â | ||||||||||
miR-10a-5p | / | / | 0.88 | Â | ||||||||||
miR-145-3p | / | / | 0.87 | Â | ||||||||||
miR-27b-3p | / | / | 0.86 | Â | ||||||||||
miR-511-5p | / | / | 0.86 | Â | ||||||||||
miR-7706 | / | / | 0.85 | Â | ||||||||||
miR-99b-5p | / | / | 0.85 | Â | ||||||||||
miR-143-3p | / | / | 0.83 | Â | ||||||||||
miR-486-3p | / | / | 0.83 | Â | ||||||||||
miR-99a-5p | / | / | 0.83 | Â | ||||||||||
miR-223-3p | / | / | 0.82 | Â | ||||||||||
mRNA | Â | Â | Â | Â | ||||||||||
Hu, 2017 [44]a | China | Case-controld | 20/15 | / | / | Serum | I-IV | HC | LPHN-CHDC biochip | GPC1 mRNA | 95 | 93 | 0.94 | / |
snoRNA | Â | Â | Â | Â | ||||||||||
Kitagawa, 2019 [53]a | Japan | Case–control | 27/13 | / | 63/31 | Serum | I-III | BGD | qPCR | SNORA14B | 93e | 69e | 0.88 | / |
SNORA18 | 81e | 84e | 0.88 | / | ||||||||||
SNORA25 | 92e | 76e | 0.90 | / | ||||||||||
SNORA74A | 92e | 84e | 0.91 | / | ||||||||||
SNORD22 | 70e | 93e | 0.86 | / | ||||||||||
snoRNA | Â | Â | Â | Â | ||||||||||
Kitagawa, 2019 [53] | Japan | Case–control | 27/13 | / | 63/31 | Serum | I-III | BGD | qPCR | CCDC88A | 55e | 92e | 0.72 | / |
ARF6 | 85e | 92e | 0.94 | / | ||||||||||
Vav3 | 74e | 85e | 0.84 | / | ||||||||||
WASF2 | 93e | 84e | 0.94 | / | ||||||||||
8/13 | / | NA/31 | Serum | I-IIA | BGD | qPCR | SNORA14B | / | / | 0.86 | / | |||
SNORA18 | / | / | 0.91 | / | ||||||||||
SNORA25 | 100e | 78e | 0.91 | / | ||||||||||
SNORA74A | 100e | 84e | 0.95 | / | ||||||||||
SNORD22 | / | / | 0.97 | / | ||||||||||
CCDC88A | / | / | 0.73 | / | ||||||||||
ARF6 | 100e | 92e | 0.98 | / | ||||||||||
Vav3 | / | / | 0.89 | / | ||||||||||
WASF2 | 100e | 84e | 0.97 | / | ||||||||||
19/13 | / | NA/31 | Serum | IIB-III | BGD | qPCR | SNORA14B | / | / | 0.88 | / | |||
SNORA18 | / | / | 0.88 | / | ||||||||||
SNORA25 | 93e | 77e | 0.90 | / | ||||||||||
SNORA74A | 93e | 85e | 0.91 | / | ||||||||||
SNORD22 | / | / | 0.86 | / | ||||||||||
CCDC88A | / | / | 0.72 | / | ||||||||||
ARF6 | 85e | 92e | 0.94 | / | ||||||||||
Vav3 | / | / | 0.84 | / | ||||||||||
WASF2 | 93e | 84e | 0.94 | / |