Table 1 Characteristics of patients with recurrent metastatic breast cancer by age (years) at diagnosis from a breast cancer cohort in China between 1989 and 2020
Characteristics | All (n= 1,636) | < 40 (n= 363) | 40–64 (n= 1,173) | ≥ 65 (n= 100) | P |
|---|---|---|---|---|---|
Year at diagnosis | 0.099 | ||||
1989–2007 | 490 (29.95) | 98 (27) | 354 (30.18) | 38 (38.00) | |
2008–2020 | 1,146 (70.05) | 265 (73) | 819 (69.82) | 62 (62.00) | |
Ethnic group | 0.799 | ||||
Minority | 28 (1.71) | 6 (1.65) | 20 (1.71) | 2 (2.00) | |
Han | 1,472 (89.98) | 322 (88.71) | 1,058 (90.2) | 92 (92.00) | |
Unknown | 136 (8.31) | 35 (9.64) | 95 (8.1) | 6 (6.00) | |
Insurance type | 0.004 | ||||
Urban schemes | 1,159 (70.84) | 249 (68.6) | 823 (70.16) | 87 (87.00) | |
Rural schemes | 462 (28.24) | 112 (30.85) | 337 (28.73) | 13 (13.00) | |
Unknown | 15 (0.92) | 2 (0.55) | 13 (1.11) | 0 | |
Education (years) | < 0.001 | ||||
≤ 6 | 241 (14.73) | 23 (6.34) | 200 (17.05) | 18 (18.00) | |
7–9 | 485 (29.65) | 106 (29.2) | 364 (31.03) | 15 (15.00) | |
10–12 | 293 (17.91) | 66 (18.18) | 205 (17.48) | 22 (22.00) | |
> 12 | 250 (15.28) | 95 (26.17) | 141 (12.02) | 14 (14.00) | |
Unknown | 367 (22.43) | 73 (20.11) | 263 (22.42) | 31 (31.00) | |
Marital status | < 0.001 | ||||
Non-married | 23 (1.41) | 15 (4.13) | 8 (0.68) | 0 | |
Married | 1,487 (90.89) | 315 (86.78) | 1,078 (91.9) | 94 (94.00) | |
Unknown | 126 (7.7) | 33 (9.09) | 87 (7.42) | 6 (6.00) | |
BMI (kg/m2) | < 0.001 | ||||
< 23 | 616 (37.65) | 175 (48.21) | 409 (34.87) | 32 (32.00) | |
≥ 23 | 654 (39.98) | 117 (32.23) | 500 (42.63) | 37 (37.00) | |
Unknown | 366 (22.37) | 71 (19.56) | 264 (22.51) | 31 (31.00) | |
Menopausal status | < 0.001 | ||||
Premenopausal | 918 (56.11) | 345 (95.04) | 572 (48.76) | 1 (1.00) | |
Postmenopausal | 713 (43.58) | 16 (4.41) | 599 (51.07) | 98 (98.00) | |
Unknown | 5 (0.31) | 2 (0.55) | 2 (0.17) | 1 (1.00) | |
Comorbidity | 0.016 | ||||
No | 1,435 (87.71) | 332 (91.46) | 1,021 (87.04) | 82 (82.00) | |
Yes | 201 (12.29) | 31 (8.54) | 152 (12.96) | 18 (18.00) | |
Hormone receptor status | 0.232 | ||||
Negative | 525 (32.09) | 103 (28.37) | 391 (33.33) | 31 (31.00) | |
Positive | 1,015 (62.04) | 242 (66.67) | 708 (60.36) | 65 (65.00) | |
Unknown | 96 (5.87) | 18 (4.96) | 74 (6.31) | 4 (4.00) | |
HER2 status | < 0.001 | ||||
Negative | 949 (58.01) | 243 (66.94) | 640 (54.56) | 66 (66.00) | |
Positive | 398 (24.33) | 67 (18.46) | 312 (26.6) | 19 (19.00) | |
Unknown | 289 (17.67) | 53 (14.6) | 221 (18.84) | 15 (15.00) | |
Ki-67 level | < 0.001 | ||||
< 14% | 222 (13.57) | 37 (10.19) | 155 (13.21) | 30 (30.00) | |
≥ 14% | 1,129 (69.01) | 262 (72.18) | 812 (69.22) | 55 (55.00) | |
Unknown | 285 (17.42) | 64 (17.63) | 206 (17.56) | 15 (15.00) | |
Molecular subtype | 0.001 | ||||
Luminal A | 160 (9.78) | 41 (11.29) | 99 (8.44) | 20 (20.00) | |
Luminal B | 714 (43.64) | 173 (47.66) | 502 (42.8) | 39 (39.00) | |
HER2-positive | 187 (11.43) | 28 (7.71) | 150 (12.79) | 9 (9.00) | |
Triple-negative | 289 (17.67) | 65 (17.91) | 205 (17.48) | 19 (19.00) | |
Unknown | 286 (17.48) | 56 (15.43) | 217 (18.5) | 13 (13.00) | |
Tumor sizea | 0.078 | ||||
T1 | 295 (18.03) | 62 (17.08) | 206 (17.56) | 27 (27.00) | |
T2 | 759 (46.39) | 161 (44.35) | 549 (46.8) | 49 (49.00) | |
T3 | 161 (9.84) | 43 (11.85) | 113 (9.63) | 5 (5.00) | |
T4 | 199 (12.16) | 40 (11.02) | 147 (12.53) | 12 (12.00) | |
Unknown | 222 (13.57) | 57 (15.7) | 158 (13.47) | 7 (7.00) | |
Nodal statusa | 0.734 | ||||
N0 | 417 (25.49) | 98 (27) | 287 (24.47) | 32 (32.00) | |
N1 | 439 (26.83) | 102 (28.1) | 313 (26.68) | 24 (24.00) | |
N2 | 273 (16.69) | 59 (16.25) | 199 (16.97) | 15 (15.00) | |
N3 | 386 (23.59) | 77 (21.21) | 285 (24.3) | 24 (24.00) | |
Unknown | 121 (7.4) | 27 (7.44) | 89 (7.59) | 5 (5.00) | |
Metastatic sites | |||||
Bone | 0.117 | ||||
No | 1,101 (67.30) | 244 (67.22) | 799 (68.12) | 58 (58.00) | |
Yes | 535 (32.70) | 119 (32.78) | 374 (31.88) | 42 (42.00) | |
Brain | 0.124 | ||||
No | 1,431 (87.47) | 317 (87.33) | 1,020 (86.96) | 94 (94.00) | |
Yes | 205 (12.53) | 46 (12.67) | 153 (13.04) | 6 (6.00) | |
Viscera | 0.060 | ||||
No | 701 (42.85) | 140 (38.57) | 510 (43.48) | 51 (51.00) | |
Yes | 935 (57.15) | 223 (61.43) | 663 (56.52) | 49 (49.00) | |
Contralateral breast | 0.065 | ||||
No | 1,503 (91.87) | 323 (88.98) | 1,086 (92.58) | 94 (94.00) | |
Yes | 133 (8.13) | 40 (11.02) | 87 (7.42) | 6 (6.00) | |
Others | 0.089 | ||||
No | 1,318 (80.56) | 291 (80.17) | 938 (79.97) | 89 (89.00) | |
Yes | 318 (19.44) | 72 (19.83) | 235 (20.03) | 11 (11.00) | |
Local recurrence | 0.622 | ||||
No | 1,178 (72.00) | 258 (71.07) | 844 (71.95) | 76 (76.00) | |
Yes | 458 (28.00) | 105 (28.93) | 329 (28.05) | 24 (24.00) | |
Histological type | 0.071 | ||||
Ductal | 1,368 (83.62) | 304 (83.75) | 975 (83.12) | 89 (89.00) | |
Others | 132 (8.07) | 34 (9.37) | 89 (7.59) | 9 (9.00) | |
Unknown | 136 (8.31) | 25 (6.89) | 109 (9.29) | 2 (2.00) | |
Histological grade | 0.265 | ||||
I/II | 318 (19.44) | 65 (17.91) | 226 (19.27) | 27 (27.00) | |
III | 685 (41.87) | 161 (44.35) | 484 (41.26) | 40 (40.00) | |
Unknown | 633 (38.69) | 137 (37.74) | 463 (39.47) | 33 (33.00) | |
Surgery | 0.767 | ||||
No | 63 (3.85) | 16 (4.41) | 44 (3.75) | 3 (3.00) | |
Yes | 1,573 (96.15) | 347 (95.59) | 1,129 (96.25) | 97 (97.00) | |
Anyradiotherapy | 0.002 | ||||
No | 807 (49.33) | 158 (43.53) | 586 (49.96) | 63 (63.00) | |
Yes | 829 (50.67) | 205 (56.47) | 587 (50.04) | 37 (37.00) | |
Any chemotherapy | 0.006 | ||||
No | 242 (14.79) | 41 (11.29) | 177 (15.09) | 24 (24.00) | |
Yes | 1,394 (85.21) | 322 (88.71) | 996 (84.91) | 76 (76.00) | |
Any hormonal therapy | 0.012 | ||||
No | 605 (36.98) | 114 (31.4) | 460 (39.22) | 31 (31.00) | |
Yes | 1,031 (63.02) | 249 (68.6) | 713 (60.78) | 69 (69.00) | |
Any targeted therapy | 0.096 | ||||
No | 1,431 (87.47) | 309 (85.12) | 1,029 (87.72) | 93 (93.00) | |
Yes | 205 (12.53) | 54 (14.88) | 144 (12.28) | 7 (7.00) | |