Fig. 9

Comparison of survival prediction ability among various prognostic gene signatures in HNSCC. The tROC and C-index analyses were used to compare the predictive power of various gene signatures. Three gene signatures included were defined as follows: the nine-gene signature were constructed in our study; the eight-gene signature (CBX3, GNA12, P4HA1, PLAU, PPL, RAB25, EPHX3, and HLF) was constructed by Baoling Liu et al.; the ten-gene signature (IL2RA, CCL5, SLC2A6, PTX3, PDGFA, INHBA, HS3ST1, TGFBI, GAS7, and RAl14) was constructed by Zhaoyi Lu et al. A The tROC analysis showed that the predictive ability of the nine-gene signature was better than that of the other two gene signatures within eight years. B C-index analysis indicated that the prediction results of the nine-gene signature were basically consistent with the survival results actually observed in HNSCC