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Table 3 Effect of chemosensitizers on SN38-resistant T47D sublines

From: Characterization of SN38-resistant T47D breast cancer cell sublines overexpressing BCRP, MRP1, MRP2, MRP3, and MRP4

 

Chemosenensitizing index of chemosensitizers

verapamil (μM)

PSC833 (nM)

TMF (μM)

Probenecid (μM)

Genistein (μM)

 

1

10

5

50

5

50

5

50

1

10

SN120

0.56

0.88

0.67

1.30

3.01

7.73

1.31

1.72

1.28

3.90

SN150

0.48

0.50

0.65

0.60

15.95

10.56

2.00

1.99

7.53

10.78

  1. \(\mathrm{Chemosensitizing}\;\mathrm{index}=\frac{{\mathrm{IC}}_{50}\;\mathrm{of}\;\mathrm{SN}38\;\mathrm{in}\;\mathrm{the}\;\mathrm{absence}\;\mathrm{of}\;\mathrm{chemosensitizer}}{{\mathrm{IC}}_{50}\;\mathrm{of}\;\mathrm{SN}38\;\mathrm{in}\;\mathrm{the}\;\mathrm{presence}\;\mathrm{of}\;\mathrm{chemosensitizer}}\) 
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BMC Cancer

ISSN: 1471-2407

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