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Fig. 3 | BMC Cancer

Fig. 3

From: Characterization of SN38-resistant T47D breast cancer cell sublines overexpressing BCRP, MRP1, MRP2, MRP3, and MRP4

Fig. 3

Sensitivity of SN38-resistant T47D sublines to SN38 in the presence of various chemosensitizers. The effects of several chemosensitizers, including Pgp [verapamil, PSC833, and 7,3′,4-trimethoxyflavone (TMF)], MRP (probenecid), and BCRP (genistein) inhibitors, were assessed on SN38-resistant T47D sublines. Among the Pgp inhibitors, only TMF showed chemosensitizing effects on SN38 in a concentration-dependent manner. Probenecid and genistein also sensitized SN38-resistant T47D sublines to SN38 in a concentration-dependent manner. (n = 3). Vp, verapamil; TMF, 7,3′,4-trimethoxyflavone; PB, probenecid; GS, genistein

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BMC Cancer

ISSN: 1471-2407

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