Variables | Univariate | p-value | Multivariate | p-value |
---|---|---|---|---|
HR | HR | |||
(95% CI) | (95% CI) | |||
Second-line chemotherapy | ||||
 Platinum-doublet vs Single agent | 0.54 |  < 0.01 | 0.53 |  < 0.01 |
(0.40 to 0.73) | Â | (0.39 to 0.73) | Â | |
Age | ||||
  ≥ 75 years vs < 75 years | 0.79 | 0.41 | 0.82 | 0.51 |
(0.45 to 1.34) | Â | (0.45 to 1.49) | Â | |
Sex | ||||
 Female vs Male | 0.57 | 0.02 | 0.55 | 0.01 |
(0.36 to 0.91) | Â | (0.34 to 0.88) | Â | |
ECOG PS | ||||
 0/1 vs 2 | 2.15 | 0.28 | 2.59 | 0.19 |
(0.53 to 8.65) | Â | (0.63 to 10.6) | Â | |
Smoking status | ||||
 Never or former smoker vs Current smoker | 0.84 | 0.23 | 0.94 | 0.70 |
(0.63 to 1.12) | Â | (0.70 to 1.27) | Â | |
Histology | ||||
 Adenocarcinoma vs Non-adenocarcinoma | 0.98 | 0.87 | 1.14 | 0.38 |
(0.73 to 1.30) | Â | (0.85 to 1.54) | Â | |
Clinical stage | ||||
 IIIA vs IIIB | 0.62 |  < 0.01 | 0.67 |  < 0.01 |
(0.47 to 0.82) | Â | (0.50 to 0.90) | Â | |
Respiratory comorbidity | ||||
 No vs Yes | 0.95 | 0.95 | 0.95 | 0.75 |
(0.71 to 1.27) | Â | (0.70 to 1.29) | Â | |
Response to first-line chemoradiotherapy | ||||
 CR or PR vs not CR nor PR | 0.94 | 0.71 | 0.94 | 0.72 |
(0.70 to 1.28) | Â | (0.68 to 1.30) | Â | |
Duration from the start of first-line therapy to second-line therapy | ||||
  ≥ 8.6 months vs < 8.6 months | 0.82 | 0.16 | 0.74 | 0.048 |
(0.62 to 1.08) | Â | (0.55 to 0.997) | Â |