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Table 2 Relationship between clinical parameters and lymphocyte subsets in high-risk group before therapy (T1) (n=71)

From: Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma

Parameters

Age

p

Sex

p

Smoking

p

Drinking

p

Family history of cancer

p

Histology

p

T classification

p

N classification

p

UICC stage

p

<50 vs ≥50

Male vs Female

Yes vs No

Yes vs No

Yes vs No

K vs NK

pT1-2 vs pT3-4

pN0-1 vs pN2-3

I-II vs III-IV

CD3+ %

71.05±9.96

67.03±12.34

.039

68.89±11.29

67.36±12.81

.632

69.78±11.67

67.10±11.57

.335

65.73±14.93

69.74±9.71

.181

69.30±11.03

67.95±12.11

.635

72.00±3.98

68.29±11.90

.539

71.54±4.65

68.17±12.12

.742

68.34±11.87

68.72±11.47

.234

70.75±6.15

68.43±11.76

.122

CD3+ count

1.22±0.56

1.00±0.33

.035

1.08±0.42

1.08±0.49

.950

1.15±0.46

1.01±0.40

.185

1.04±0.43

1.10±0.44

.556

1.08±0.33

1.09±0.50

.946

1.17±0.38

1.08±0.44

.680

1.15±0.60

1.08±0.42

.372

1.10±0.40

1.05±0.49

.624

0.90±0.43

1.09±0.44

.160

CD3+CD4+ %

38.88±7.84

37.92±10.05

.925

38.04±9.41

38.94±9.00

.723

39.68±9.36

36.74±9.02

.183

34.87±9.74

39.80±8.70

.037

38.03±8.63

38.44±9.76

.856

34.83±4.33

38.48±9.44

.447

35.27±8.00

38.60±9.38

.492

39.30±8.23

36.86±10.47

.574

36.50±7.21

38.32±9.34

.507

CD3+CD4+ count

0.65±0.29

0.57±0.22

.366

0.59±0.24

0.62±0.29

.652

0.64±0.26

0.55±0.23

.114

0.55±0.23

0.62±0.26

.234

0.58±0.17

0.61±0.29

.596

0.57±0.20

0.60±0.25

.809

0.59±0.41

0.60±0.23

.207

0.63±0.22

0.56±0.28

.205

0.47±0.27

0.60±0.25

.154

CD3+CD8+ %

26.55±8.40

23.47±9.12

.014

25.07±8.96

23.19±8.93

.444

24.49±9.30

24.71±8.63

.918

24.99±9.21

24.42±8.89

.808

25.89±10.22

23.70±7.91

.313

3.30±3.48

24.26±9.05

.190

26.87±5.85

24.35±9.20

.537

23.58±8.93

25.99±8.88

.308

27.00±4.24

24.53±9.03

.814

CD3+CD8+ count

0.48±0.28

0.35±0.19

.011

0.41±0.24

0.38±0.24

.660

0.42±0.26

0.38±0.21

.505

0.40±0.24

0.40±0.24

.916

0.41±0.23

0.39±0.24

.663

0.50±0.19

0.39±0.24

.406

0.41±0.19

0.40±0.24

.949

0.39±0.22

0.41±0.26

.710

0.33±0.08

0.40±0.24

.687

CD4/CD8 ratio

1.64±0.76

1.90±0.95

.034

1.71±0.73

2.07±1.24

.144

1.84±0.77

1.76±1.01

.741

1.59±0.76

1.90±0.93

.174

1.76±0.96

1.83±0.85

.739

1.18±0.30

1.84±0.90

.148

1.36±0.40

1.85±0.92

.439

1.95±0.96

1.59±0.75

.239

1.35±0.49

1.81±0.90

.726

CD3-CD56+ %

16.42±7.90

20.53±11.40

.042

19.28±10.45

18.27±10.48

.724

18.35±9.76

19.75±11.14

.574

21.65±13.34

17.84±8.66

.155

19.46±10.81

18.72±10.21

.773

13.75±5.01

19.34±10.57

.300

16.94±1.71

19.25±10.92

.702

18.34±10.99

19.95±9.62

.232

17.80±1.84

19.06±10.54

.131

CD3-CD56+ count

0.28±0.16

0.33±0.30

.205

0.32±0.27

0.29±0.22

.757

0.30±0.26

0.32±0.26

.836

0.36±0.37

0.29±0.19

.239

0.32±0.27

0.30±0.25

.733

0.24±0.15

0.31±0.26

.580

0.26±0.10

0.32±0.27

.669

0.32±0.28

0.30±0.23

.306

0.22±0.07

0.31±0.26

.394

CD3-CD19+ %

10.58±5.80

9.22±5.00

.505

9.04±3.91

11.71±7.97

.065

9.27±4.86

10.21±5.79

.459

10.19±6.65

9.51±4.64

.622

8.50±3.80

10.56±6.04

.109

10.53±6.39

9.67±5.29

.757

9.37±3.65

9.76±5.48

.988

10.54±5.64

8.59±4.66

.287

9.60±1.98

9.72±5.38

.949

CD3-CD19+ count

0.17±0.09

0.14±0.09

.414

0.14±0.07

0.18±0.13

.124

0.15±0.10

0.14±0.08

.680

0.16±0.12

0.15±0.07

.629

0.13±0.06

0.16±0.11

.093

0.16±0.09

0.15±0.09

.803

0.13±0.03

0.15±0.09

.733

0.17±0.10

0.13±0.08

.083

0.12±0.02

0.15±0.09

.814

CD3+CD56+ %

3.20±2.62

2.56±1.22

.189

2.69±1.32

3.11±2.98

.414

2.65±1.35

2.96±2.32

.497

2.86±1.54

2.77±2.01

.854

2.63±1.33

2.91±2.17

.545

2.13±0.91

2.84±1.91

.463

2.60±1.25

2.82±1.93

.980

3.03±2.17

2.48±1.31

.545

3.30±0.57

2.78±1.89

.399

CD3+CD56+ count

0.06±0.07

0.04±0.02

.196

0.04±0.02

0.06±0.08

.228

0.04±0.03

0.05±0.06

.745

0.05±0.03

0.05±0.05

.959

0.04±0.02

0.05±0.06

.442

0.04±0.02

0.05±0.05

.681

0.04±0.01

0.05±0.05

.819

0.05±0.06

0.04±0.02

.260

0.04±0.01

0.05±0.05

.289

CD4+CD45RA+ %

12.79±4.03

8.45±5.02

.026

9.58±5.23

11.40±4.61

.194

10.16±5.40

9.91±4.85

.836

8.40±5.60

10.78±4.75

.070

10.06±4.37

10.03±5.62

.981

10.25±2.79

10.03±5.23

.934

11.31±4.94

9.90±5.15

.700

10.88±4.51

8.90±5.72

.390

12.55±3.18

9.97±5.15

.049

CD4+CD45RA+ count

0.22±0.13

0.13±0.10

.040

0.16±0.12

0.19±0.11

.349

0.18±0.13

0.15±0.10

.354

0.14±0.12

0.17±0.12

.229

0.15±0.08

0.17±0.14

.642

0.17±0.07

0.16±0.12

.924

0.20±0.19

0.16±0.11

.212

0.18±0.10

0.14±0.14

.321

0.16±0.10

0.16±0.12

.047

CD4+CD45RA- %

22.60±5.99

24.94±7.73

.220

24.20±7.35

23.74±6.86

.818

25.32±7.26

22.74±6.96

.131

22.85±7.24

24.64±7.17

.334

23.82±6.36

24.26±7.78

.802

20.78±5.69

24.28±7.25

.347

20.33±5.80

24.50±7.24

.350

24.59±6.04

23.39±8.57

.141

21.95±5.30

24.15±7.25

.853

CD4+CD45RA- count

0.38±0.17

0.37±0.14

.937

0.37±0.14

0.38±0.17

.935

0.40±0.15

0.34±0.15

.085

0.36±0.15

0.38±0.15

.496

0.36±0.11

0.38±0.17

.625

0.34±0.14

0.38±0.15

.606

0.34±0.22

0.38±0.14

.239

0.39±0.13

0.35±0.17

.370

0.29±0.17

0.38±0.15

.364

CD4+CD45RA+/CD4+CD45RA- ratio

0.60±0.24

0.36±0.22

.003

0.42±0.25

0.52±0.25

.194

0.43±0.26

0.47±0.25

.470

0.39±0.28

0.47±0.24

.192

0.46±0.27

0.44±0.24

.644

0.55±0.30

0.44±0.25

.426

0.57±0.21

0.43±0.26

.546

0.47±0.22

0.42±0.29

.609

0.57±0.01

0.44±0.26

.233

CD4+CD45RO+ %

22.43±6.03

24.79±7.68

.244

23.93±7.32

23.91±6.90

.801

25.01±7.27

22.74±6.97

.112

22.82±7.23

24.42±7.16

.322

23.64±6.51

24.12±7.66

.831

20.48±0.24

24.13±7.25

.320

20.14±5.21

24.34±7.26

.331

24.54±6.05

23.09±8.51

.123

21.40±3.39

24.00±7.25

.821

CD4+CD45RO+ count

0.37±0.16

0.37±0.14

.902

0.37±0.14

0.38±0.17

.930

0.40±0.14

0.34±0.15

.092

0..36±0.15

0.38±0.15

.471

0.36±0.11

0.38±0.17

.611

0.33±0.13

0.37±0.15

.611

0.34±0.21

0.37±0.14

.208

0.39±0.13

0.35±0.17

.314

0.28±0.15

0.37±0.15

.355

CD8+CD38+ %

5.78±2.61

6.33±3.27

.654

6.34±3.13

5.51±2.75

.319

5.86±2.96

6.41±3.14

.447

6.57±3.24

5.93±2.96

.415

6.38±3.26

5.95±2.90

.558

5.18±1.84

6.18±3.09

.523

6.39±2.49

6.10±3.11

.317

5.92±3.18

6.40±2.86

.230

7.30±0.42

6.09±3.07

.149

CD8+CD38+ count

0.10±0.06

0.10±0.08

.996

0.10±0.08

0.09±0.07

.489

0.10±0.07

0.10±0.08

.765

0.11±0.09

0.09±0.06

.407

0.10±0.07

0.10±0.08

.819

0.09±0.06

0.10±0.08

.809

0.09±0.05

0.10±0.08

.511

0.10±0.08

0.10±0.07

.181

0.09±0.04

0.10±0.08

.459

WBC count

6.83±1.80

6.58±2.14

1.000

6.80±2.13

6.31±1.64

.380

6.62±1.93

6.74±2.13

.809

6.77±2.28

6.63±1.91

.787

6.50±2.07

6.80±1.99

.539

6.23±0.61

6.70±2.07

.649

7.00±3.54

6.64±1.82

.413

6.10±1.60

7.46±2.27

.016

5.90±0.85

6.70±2.04

.353

Neutrophil count

4.51±1.45

4.57±2.18

.557

4.65±2.08

4.23±1.38

.428

4.42±1.81

4.23±1.38

.561

4.65±2.21

4.50±1.81

.758

4.40±2.06

4.65±1.85

.595

3.95±0.58

4.58±1.98

.528

4.77±3.51

3.02±1.46

.682

3.25±1.55

2.73±1.30

.021

2.23±0.61

3.05±1.47

.262

NLR

3.13±1.66

3.63±2.97

.273

3.52±2.78

3.22±1.84

.665

3.13±2.09

3.78±3.00

.291

3.74±3.40

3.31±2.13

.517

3.09±2.24

3.69±2.77

.334

2.62±1.32

3.49±2.62

.511

4.43±5.95

4.52±1.72

.588

3.97±1.34

5.34±2.32

.096

4.10±0.28

4.56±1.96

.227

Monocyte count

0.63±0.20

0.52±0.22

.022

0.57±0.23

0.51±0.19

.312

0.56±0.22

0.55±0.21

.823

0.59±0.24

0.54±0.21

.381

0.49±0.20

0.60±0.22

.039

0.55±0.17

0.56±0.22

.955

0.60±0.28

0.03±0.18

.626

0.02±0.16

0.03±0.18

.088

0.00±0.00

0.03±0.17

.892

LMR

2.77±0.97

3.18±1.67

.148

2.95±1.50

3.26±1.35

.449

3.03±1.58

3.03±1.35

.987

2.97±1.78

3.05±1.31

.826

3.42±1.76

2.76±1.16

.058

3.16±0.85

3.02±1.49

.852

3.14±1.55

3.34±1.96

.901

2.82±1.48

4.30±3.41

.316

3.51±1.16

3.44±2.60

.156

Platelet count

271.00±78.31

218.62±61.59

.017

225.45±65.3

274.17±81.1

.012

224.03±73.92

252.79±68.33

.094

225.09±75.31

243.51±70.89

.324

234.14±75.51

240.33±70.73

.725

217.50±91.30

239.01±71.63

.567

208.29±73.94

229.28±74.20

.248

210.34±50.11

263.23±117.77

.281

205.00±25.46

233.49±89.85

.195

PLR

189.98±102.5

161.59±72.8

.344

159.97±69.4

207.35±115.9

.041

152.83±68.16

192.83±97.47

.048

168.23±81.97

173.67±87.51

.805

158.44±68.14

181.34±95.01

.269

137.92±69.29

174.02±86.15

.415

157.01±105.76

173.62±83.60

.265

166.70±86.60

179.21±84.37

.775

147.12±62.22

172.71±86.09

.152

SII

873.96±569.6

820.65±815.0

.863

812.6±760.9

921.4±647.4

.589

713.74±575.1

977.75±857.2

.129

868.2±929.6

827.6±632.7

.831

739.94±630.8

909.38±792.6

.341

566.95±321.5

856.48±746.3

.446

1034.0±1632.8

818.97±578.7

.498

684.16±480.17

1053.38±943.3

.200

594.39±213.5

847.29±739.8

.146

ALB

42.05±4.04

42.70±3.84

.600

42.92±3.82

41.09±3.92

.085

43.49±3.79

41.34±3.76

.019

43.04±3.16

42.20±4.20

.404

42.33±4.01

42.55±3.87

.815

41.25±5.84

42.53±3.81

.527

41.06±3.60

42.61±3.93

.230

42.83±3.34

41.95±4.57

.522

42.90±2.83

42.45±3.94

.719

LDH

219.92±53.2

240.07±103.7

.205

230.92±94.2

237.89±72.4

.776

232.32±78.04

233.09±100.3

.971

251.6±105.1

224.2±80.1

.232

228.62±86.35

235.50±91.28

.751

214.50±44.03

233.78±90.78

.676

263.86±181.1

241.03±71.9

.375

233.98±70.78

243.03±75.12

.095

168.50±4.95

239.81±72.3

.101

  1. Abbreviations: K keratinizing, NK non-keratinizing, NLR neutrophil count/Lymphocyte count, LMR lymphocyte count/monocyte count, PLR Platelet count/Lymphocyte count, SII Platelet count×Neutrophil count/Lymphocyte count, ALB albumin, LDH lactate dehydrogenase
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