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Table 3 Metadata of the 13 studies included in the systematic review

From: Genetic and RNA-related molecular markers of trastuzumab-chemotherapy-associated cardiotoxicity in HER2 positive breast cancer: a systematic review

Author

Date of Publication

Journal

Database

Study design

No of patients

Study Duration (months)

Gómez Peña et al. [15]

2015

Pharmacogenetics and Genomics

Medline

CCS

78

12

Beauclair et al. [16]

2007

Annals of Oncology

Medline

CCS

61

22.4

Lemieux et al. [17]

2013

Anticancer Research

Medline

CCS

73

NA

Roca L et al. [2]

2013

Breast Cancer Research and Treatment

Medline

CCS

132

46.8

Tan et al. [18]

2020

International Journal of Clinical and Experimental Pathology

Medline

CCS

91

15

Peddi et al. [19]

2022

Clinical Cancer Research

Medline

RCT

662

120

Stanton et al. [20]

2015

BMC Cancer

Medline

CCS

140

NA

Boekhout et al. [21]

2016

JAMA oncology

Medline

CCS

206

21

Serie et al. [23]

2017

Journal of cardiovascular development and disease

Medline

Post-hoc analysis

800

72

Udagawa et al. [24]

2018

Cancer science

Medline

CCS

243

NA

Nakano et al. [25]

2019

Biological and pharmaceutical bulletin

Medline

CS

481

37.7

Wang et al. [26]

2019

Medicine (Baltimore)

Medline

Pilot study

3

NA

Zhang et al. [27]

2020

Frontiers in oncology

Medline

CCS

65

NA

Feng et al. [28]

2021

J Breast Cancer

Mediline

CCS

72

15

  1. Abbreviations: NA Not Available, RCT Randomized control trial, CS Cohort study, CCS Cross sectional, IV In-vitro