|
patient characteristics
|
|
gender, female
|
6 (24.00)
| |
5 (45.45)
| |
1 (7.14)
| |
|
age at first diagnosis, yr
| |
61.88 (30–81)
| |
59.91 (30–81)
| |
63.43 (51–78)
|
|
age at first diagnosis, > 63 yr
|
10 (40.00)
| |
4 (36.36)
| |
6 (42.86)
| |
|
body mass index, kg/cm2
| |
26.1 (19.1–41.6)
| |
26.3 (19.1–41.6)
| |
25.9 (22.0–32.4)
|
|
high blood pressure
|
13 (52.00)
| |
7 (63.64)
| |
6 (42.86)
| |
|
alcohol consumption
|
2 (8.00)
| |
0
| |
2 (14.29)
| |
|
smoking history
|
2 (8.00)
| |
1 (9.09)
| |
1 (7.14)
| |
|
convulsion
|
6 (24.00)
| |
1 (9.09)
| |
5 (35.71)
| |
|
cardiovascular disease
|
7 (28.00)
| |
4 (36.36)
| |
3 (21.43)
| |
|
diabetes mellitus type II
|
4 (16.00)
| |
4 (36.36)
| |
0
| |
|
second malignoma
|
2 (8.00)
| |
1 (9.09)
| |
1 (7.14)
| |
|
chronic kidney injury
|
4 (16.00)
| |
2 (18.18)
| |
2 (14.29)
| |
|
chronic obstructive pulmonic disease
|
4 (16.00)
| |
2 (18.18)
| |
2 (14.29)
| |
|
cardiac stents
|
1 (4.00)
| |
0
| |
1 (7.14)
| |
|
adipositas
|
4 (16.00)
| |
2 (18.18)
| |
2 (14.29)
| |
|
colorectal cancer
|
|
UICC stage
|
n/a
|
2 (8.00)
| |
0
| |
2 (14.29)
| |
|
I
|
3 (12.00)
| |
1 (9.09)
| |
2 (14.29)
| |
|
II
|
1 (4.00)
| |
1 (9.09)
| |
0
| |
|
III
|
10 (40.00)
| |
6 (54.55)
| |
4 (28.57)
| |
|
IV
|
9 (36.00)
| |
3 (27.27)
| |
6 (42.86)
| |
|
Grading
|
n/a
|
2 (8.00)
| |
1 (9.09)
| |
1 (7.14)
| |
|
G1
|
9 (36.00)
| |
6 (54.55)
| |
3 (21.43)
| |
|
G2
|
8 (32.00)
| |
3 (27.27)
| |
5 (35.71)
| |
|
G3
|
6 (24.00)
| |
1 (9.09)
| |
5 (35.71)
| |
|
pulmonary metastasis
|
18 (72.00)
| |
7 (63.64)
| |
11 (78.57)
| |
|
time from first diagnosis to pulmonary metastasis, mo
| |
33.44 (0–103)
| |
37.43 (0–82)
| |
30.91 (0–703)
|
|
liver metastasis
|
15 (60.00)
| |
8 (72.73)
| |
7 (50.00)
| |
|
time from first diagnosis to liver metastasis, mo
| |
19.27 (0–98)
| |
30.29 (0–98)
| |
9.63 (0–40)
|
|
other systemic metastasis (without brain)
|
9 (36.00)
| |
3 (27.27)
| |
6 (42.86)
| |
|
number chemotherapeutic drugs
| |
3.08 (0–8)
| |
3.64 (0–8)
| |
2.64 (0–7)
|
|
systemic chemotherapy
|
w/o
|
2 (8.00)
| |
0
| |
2 (14.29)
| |
|
adjuvant
|
14 (56.00)
| |
11 (100.00)
| |
3 (21.43)
| |
|
neoadjuvant + adjuvant
|
9 (36.00)
| |
0
| |
9 (64.29)
| |
|
systemic radiation therapy
|
w/o
|
14 (56.00)
| |
8 (72.73)
| |
6 (42.86)
| |
|
neoadjuvant
|
4 (16.00)
| |
0
| |
4 (28.57)
| |
|
adjuvant
|
7 (28.00)
| |
3 (27.27)
| |
4 (28.57)
| |
|
brain metastasis
|
|
age at diagnosis of BM, yr
| |
65.80 (36–82)
| |
64.27 (36–82)
| |
67.00 (51–78)
|
|
time from first diagnosis to BM, mo
| |
47.16 (0–102)
| |
52.91 (5–95)
| |
42.64 (0–102)
|
|
number of BMs
|
1
|
14 (56.00)
| |
9 (81.82)
| |
5 (35.71)
| |
|
2
|
3 (12.00)
| |
0
| |
3 (21.43)
| |
|
3
|
6 (24.00)
| |
1 (9.09)
| |
5 (35.71)
| |
|
> 3
|
2 (8.00)
| |
1 (9.09)
| |
1 (7.14)
| |
|
localization of BM
|
cerebral
|
9 (36.00)
| |
6 (54.55)
| |
3 (21.43)
| |
|
cerebellar
|
6 (24.00)
| |
3 (27.27)
| |
3 (21.43)
| |
|
both
|
10 (40.00)
| |
2 (18.18)
| |
8 (57.14)
| |
|
symptoms of BM
|
incidental finding
|
4 (16.00)
| |
3 (27.27)
| |
1 (7.14)
| |
|
unspecific CNS
|
3 (12.00)
| |
3 (27.27)
| |
0
| |
|
specific CNS
|
18 (72.00)
| |
5 (45.45)
| |
13 (92.86)
| |
|
radiation therapy, brain
|
17 (68.00)
| |
7 (63.64)
| |
10 (71.43)
| |
|
radiation therapy, modality
|
stereotactic
|
11 (64.71)
| |
5 (71.43)
| |
6 (60.00)
| |
|
whole brain
|
6 (35.29)
| |
2 (28.57)
| |
4 (40.00)
| |
|
radiation dose, Gy
| |
38.31 (25–71)
| |
33.50 (25–45)
| |
41.20 (30–71)
|
|
surgery
|
|
localization surgery
|
cerebral
|
11 (45.83)
| |
6 (54.55)
| |
5 (38.46)
| |
|
cerebellar
|
13 (54.17)
| |
5 (45.45)
| |
8 (61.54)
| |
|
cross total resection
|
13 (54.17)
| |
8 (72.73)
| |
5 (38.46)
| |
|
age at death, yr
| |
66.20 (37–81)
| |
62.56 (37–81)
| |
69.18 (51–79)
|
|
time from first diagnosis to death, mo
| |
51.75 (5–104)
| |
56.44 (9–704)
| |
47.91 (5–95)
|
|
time from BM to death, mo
| |
4.90 (0–18)
| |
6 (0–18)
| |
4 (0–9)
|
|
time from BM to death, mo [median]
| |
3.00 (0–18)
| |
3 (0–18)
| |
2 (0–9)
|
|
six-month survival, mo
|
8 (40.00)
| |
3 (33.33)
| |
5 (45.45)
| |
|
one-year survival, mo
|
2 (10.00)
| |
2 (22.22)
| |
0
| |
