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Table 2 Results of univariate and multivariate analysis of overall survival (Cox’s proportional hazard mode)

From: Survival past five years with advanced, EGFR-mutated or ALK-rearranged non-small cell lung cancer—is there a “tail plateau” in the survival curve of these patients?

  N Univariate analysis Multivariate analysis
HR(95% CI) P value HR(95% CI) P value
Sex
 Female 95 1 0.387 1 0.0082
 Male 82 1.2(0.83–1.6) 1.8 (1.2–2.8)
Age, year
  < 75 141 1 0.047 1 0.0099
75 36 1.5(1.00–2.3) 1.8 (1.2–2.9)
Smoking history
 Current or former smoker 79 1 0.16 1 0.0721
 Never smoker 93 1.3(0.90–1.8) 1.5 (0.96–2.2)
ECOG PS
 0–1 135 1 0.0002 1 0.0008
 2–4 21 2.6(1.6–4.4) 2.7 (1.5–4.7)
Driver mutation
 ALK-Rearranged 22 1 0.0602 1 0.0148
 EGFR-Mutated 155 1.7(0.98–3.1) 2.1 (1.2–3.8)
Stage
 Post operative recurrence 70 1 0.0007 1  < 0.0001
 Stage III or IV 107 1.9(1.3–2.7) 2.3 (1.5–3.4)
Presence of brain metastasis
 No 132 1 0.0009 1 0.0003
  45 1.9(1.3–2.8) 2.1 (1.4–3.2)