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Table 2 Incidence risk of cancer for patients with moderate/severe TBI compared with patients with mild TBI

From: New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study

  Before matching After matching
Variables Mild TBI Moderate/
severe TBI
Adjusted* HR
(95% CI)
p value Mild TBI Moderate/severe TBI Adjusted* HR
(95% CI)
p value
Cancer (%) Cancer (%) Cancer (%) Cancer (%)
Overall 710 (4.1) 753 (4.2) 1.14(1.03–1.27) 0.0127 608(4.1) 610(4.1) 1.11(0.99–1.24) 0.0751
Sex
 Male 436 (4.4) 506 (4.2) 1.11(0.97–1.26) 0.1241 406(4.4) 377(4.1) 1.04(0.90–1.19) 0.6173
 Female 274 (3.7) 247 (4.1) 1.21(1.02–1.44) 0.0316 202(3.5) 233(4.1) 1.25(1.03–1.51) 0.0219
Age
 20–35 92 (1.3) 70 (1.1) 1.08(0.79–1.48) 0.6143 67 (1.1) 60(1.0) 1.19(0.84–1.68) 0.3393
 36–45 167 (4.4) 130 (3.5) 0.98(0.78–1.24) 0.8703 133(4.2) 108(3.4) 0.98(0.76–1.26) 0.8518
 46–55 235 (6.4) 288 (6.9) 1.35(1.13–1.60) 0.0008 211(6.3) 252(7.5) 1.29(1.07–1.55) 0.0069
 55–65 216 (8.7) 265 (7.4) 1.06(0.89–1.28) 0.5118 197(8.2) 190(7.9) 0.97(0.80–1.19) 0.7947
Comorbidity
 HTN 142 (8.3) 159 (6.4) 0.98(0.78–1.23) 0.8546 129(8.1) 118(6.4) 0.92(0.71–1.18) 0.5035
 DM 85 (7.8) 91 (5.9) 0.92(0.68–1.24) 0.5605 80(8) 68(6.1) 0.92(0.67–1.28) 0.6340
 Hyperlipidemia 67 (6.1) 70 (5.2) 1.06(0.75–1.50) 0.7403 57(5.7) 56(5.7) 1.13(0.78–1.64) 0.5106
 CAD 29 (5.0) 51 (6.8) 1.51(0.95–2.41) 0.0839 28(5.3) 41(7.1) 1.48(0.91–2.40) 0.1151
 Renal disease 11 (5.9) 31 (8.0) 2.17(1.08–4.36) 0.0303 8(4.8) 27(9.7) 2.49(1.11–5.58) 0.0273
 Stroke 25 (6.4) 57 (5.7) 1.10(0.68–1.76) 0.7254 23(6.3) 36(4.9) 1.01(0.59–1.71) 0.9787
  1. TBI traumatic brain injury, HR hazard ratio, CI confidence interval, HTN hypertension, DM diabetes mellitus, CAD coronary artery disease