Description | Gene markers | BRCA | BRCA-Basal | BRCA-Luminal | BRCA-Her2 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
None | Purity | None | Purity | None | Purity | None | Purity | ||||||||||
Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | ||
T cell | CD3D | -0.099 | 0.000 | -0.13 | 0.000 | 0.405 | 0.000 | 0.165 | 0.063 | -0.043 | 0.291 | -0.032 | 0.458 | -0.128 | 0.301 | -0.154 | 0.250 |
CD3E | -0.058 | 0.055 | -0.08 | 0.011 | 0.416 | 0.000 | 0.178 | 0.045 | -0.034 | 0.399 | -0.023 | 0.6 | -0.146 | 0.239 | -0.176 | 0.186 | |
CD2 | -0.056 | 0.063 | -0.076 | 0.016 | 0.476 | 0.000 | 0.281 | 0.001 | -0.016 | 0.683 | 0.002 | 0.962 | -0.151 | 0.223 | -0.217 | 0.102 | |
CD8 + T cell | CD8A | 0.004 | 0.903 | -0.012 | 0.699 | 0.394 | 0.000 | 0.179 | 0.043 | 0.012 | 0.773 | 0.031 | 0.475 | -0.13 | 0.292 | -0.165 | 0.216 |
CD8B | -0.102 | 0.000 | -0.127 | 0.000 | 0.4 | 0.000 | 0.3 | 0.000 | 0.01 | 0.807 | 0.007 | 0.869 | -0.146 | 0.237 | -0.171 | 0.201 | |
B cell | CD19 | -0.122 | 0.000 | -0.145 | 0.000 | 0.284 | 0.000 | - | 0.99 | -0.031 | 0.446 | -0.023 | 0.587 | -0.115 | 0.356 | -0.563 | 0.000 |
CD79A | -0.089 | 0.000 | -0.11 | 0.000 | 0.284 | 0.000 | -0.01 | 0.914 | 0.006 | 0.879 | 0.022 | 0.602 | -0.123 | 0.319 | -0.11 | 0.41 | |
Monocyte | CD86 | 0.006 | 0.843 | -0.001 | 0.976 | 0.53 | 0.000 | 0.362 | 0.000 | 0.012 | 0.757 | 0.027 | 0.525 | 0.084 | 0.5 | 0.073 | 0.587 |
CD115(CSF1R) | 0.134 | 0.000 | 0.134 | 0.000 | 0.605 | 0.000 | 0.472 | 0.000 | 0.137 | 0.000 | 0.151 | 0.000 | 0.097 | 0.432 | 0.129 | 0.336 | |
TAM | CCL2 | -0.087 | 0.000 | -0.084 | 0.000 | 0.4.3 | 0.000 | 0.261 | 0.003 | -0.042 | 0.293 | -0.02 | 0.641 | -0.051 | 0.681 | -0.02 | 0.883 |
CD68 | -0.012 | 0.681 | -0.023 | 0.466 | 0.548 | 0.000 | 0.389 | 0.000 | -0.062 | 0.127 | -0.061 | 0.158 | 0.145 | 0.242 | 0.16 | 0.230 | |
IL10 | -0.003 | 0.918 | -0.005 | 0.883 | 0.538 | 0.000 | 0.402 | 0.000 | -0.02 | 0.619 | -0.013 | 0.76 | 0.033 | 0.792 | 0.006 | 0.967 | |
M1 Macrophage | IRF5 | 0.002 | 0.952 | -0.018 | 0.571 | 0.393 | 0.000 | 0.225 | 0.011 | 0 | 0.997 | -0.7 | 0.865 | -0.014 | 0.911 | -0.017 | 0.899 |
INOS(NOS2) | -0.018 | 0.544 | -0.013 | 0.693 | 0.034 | 0.689 | 0.088 | 0.325 | 0.03 | 0.45 | 0.008 | 0.853 | 0.157 | 0.204 | 0.151 | 0.257 | |
COX2(PTGS2) | 0.007 | 0.806 | 0.015 | 0.636 | 0.128 | 0.13 | 0.202 | 0.022 | 0.128 | 0.001 | 0.134 | 0.002 | 0.185 | 0.134 | 0.156 | 0.242 | |
M2 Macrophage | CD163 | 0.04 | 0.181 | 0.035 | 0.277 | 0.589 | 0.000 | 0.46 | 0.000 | 0.076 | 0.059 | 0.088 | 0.041 | 0.177 | 0.152 | 0.207 | 0.119 |
VSIG4 | 0.084 | 0.000 | 0.073 | 0.021 | 0.511 | 0.000 | 0.383 | 0.000 | 0.096 | 0.018 | 0.093 | 0.029 | 0.155 | 0.211 | 0.179 | 0.179 | |
MS4A4A | 0.048 | 0.11 | 0.041 | 0.199 | 0.525 | 0.000 | 0.384 | 0.000 | 0.032 | 0.428 | 0.041 | 0.34 | -0.028 | 0.82 | -0.036 | 0.787 | |
Neutrophils | CD11b(ITGAM) | 0.088 | 0.000 | 0.083 | 0.000 | 0.53 | 0.000 | 0.387 | 0.000 | 0.031 | 0.443 | 0.032 | 0.461 | 0.261 | 0.033 | 0.316 | 0.019 |
CCR7 | -0.012 | 0.69 | -0.023 | 0.465 | 0.401 | 0.000 | 0.156 | 0.078 | 0.011 | 0.79 | 0.02 | 0.646 | -0.005 | 0.965 | -0.018 | 0.891 | |
Natural killer cell | KIR2DL1 | -0.074 | 0.014 | -0.093 | 0.000 | 0.188 | 0.026 | 0.032 | 0.717 | 0.004 | 0.917 | 0.002 | 0.955 | -0.077 | 0.538 | -0.083 | 0.538 |
KIR2DL3 | -0.061 | 0.043 | -0.059 | 0.065 | 0.336 | 0.000 | 0.191 | 0.030 | -0.027 | 0.496 | 0.008 | 0.86 | -0.066 | 0.595 | -0.084 | 0.532 | |
KIR2DL4 | -0.138 | 0.000 | -0.144 | 0.000 | 0.297 | 0.000 | 0.121 | 0.173 | -0.049 | 0.222 | -0.037 | 0.386 | -0.06 | 0.628 | -0.073 | 0.584 | |
KIR3DL1 | -0.068 | 0.024 | -0.078 | 0.013 | 0.335 | 0.000 | 0.19 | 0.032 | -0.006 | 0.876 | 0.002 | 0.962 | -0.004 | 0.973 | -0.034 | 0.799 | |
KIR3DL2 | -0.087 | 0.004 | -0.096 | 0.002 | 0.31 | 0.000 | 0.145 | 0.102 | -0.031 | 0.446 | 0.001 | 0.978 | -0.129 | 0.297 | -0.206 | 0.121 | |
KIR3DL3 | -0.063 | 0.038 | -0.072 | 0.022 | 0.134 | 0.115 | 0.027 | 0.766 | -0.013 | 0.741 | 0.009 | 0.83 | -0.161 | 0.194 | -0.166 | 0.212 | |
KIR2DS4 | -0.079 | 0.008 | -0.093 | 0.003 | 0.184 | 0.029 | -0.003 | 0.977 | -0.01 | 0.806 | -0.007 | 0.878 | -0.236 | 0.055 | -0.263 | 0.044 | |
Dendritic cell | HLA-DPB1 | 0.016 | 0.602 | -0.003 | 0.936 | 0.44 | 0.000 | 0.232 | 0.008 | 0.025 | 0.533 | 0.027 | 0.528 | -0.063 | 0.613 | -0.1 | 0.455 |
HLA-DQB1 | 0.016 | 0.602 | -0.071 | 0.026 | 0.387 | 0.000 | 0.211 | 0.017 | -0.019 | 0.634 | -0.013 | 0.753 | -0.088 | 0.476 | -0.102 | 0.448 | |
HLA-DRA | 0.047 | 0.118 | 0.041 | 0.197 | 0.498 | 0.000 | 0.326 | 0.000 | 0.039 | 0.33 | 0.052 | 0.228 | -0.044 | 0.722 | -0.071 | 0.596 | |
HLA-DPA1 | 0.108 | 0.000 | 0.114 | 0.000 | 0.502 | 0.000 | 0.343 | 0.000 | 0.08 | 0.048 | 0.097 | 0.024 | -0.093 | 0.454 | -0.133 | 0.319 | |
BDCA-1(CD1C) | 0.125 | 0.000 | 0.141 | 0.000 | 0.347 | 0.000 | 0.169 | 0.056 | 0.125 | 0.002 | 0.146 | 0.000 | 0.07 | 0.572 | 0.085 | 0.524 | |
BDCA-4(NRP1) | 0.216 | 0.000 | 0.213 | 0.000 | 0.597 | 0.000 | 0.524 | 0.000 | 0.066 | 0.103 | 0.055 | 0.203 | -0.019 | 0.878 | 0.004 | 0.979 | |
CD11c(ITGAX) | -0.005 | 0.863 | -0.011 | 0.722 | 0.515 | 0.000 | 0.338 | 0.000 | -0.044 | 0.277 | -0.04 | 0.352 | 0.055 | 0.656 | 0.099 | 0.461 | |
Helper T cell 1 (TH1) | T -bet (TBX21) | -0.069 | 0.022 | -0.095 | 0.003 | 0.441 | 0.000 | 0.247 | 0.005 | -0.002 | 0.958 | 0.017 | 0.691 | 0.076 | 0.539 | -0.117 | 0.382 |
STAT4 | 0.032 | 0.293 | 0.018 | 0.573 | 0.548 | 0.000 | 0.388 | 0.000 | 0.038 | 0.351 | 0.041 | 0.334 | -0.191 | 0.122 | -0.223 | 0.092 | |
STAT1 | 0.068 | 0.024 | 0.061 | 0.054 | 0.501 | 0.000 | 0.388 | 0.000 | 0.03 | 0.451 | 0.036 | 0.398 | 0.077 | 0.537 | 0.007 | 0.96 | |
IFNG | -0.14 | 0.000 | -0.162 | 0.000 | 0.359 | 0.000 | 0.186 | 0.036 | -0.032 | 0.423 | -0.016 | 0.705 | -0/019 | 0.88 | -0.034 | 0.798 | |
TNF | -0.116 | 0.000 | -0.097 | 0.002 | 0.278 | 0.000 | 0.167 | 0.060 | 0.012 | 0.773 | 0.047 | 0.275 | 0.019 | 0.876 | 0.058 | 0.663 | |
Regulatory cell (Treg) | FOXP3 | -0.128 | 0.000 | -0.136 | 0.000 | 0.394 | 0.000 | 0.175 | 0.048 | -0.11 | 0.006 | -0.101 | 0.019 | -0.12 | 0.331 | -0.176 | 0.187 |
CCR8 | 0.021 | 0.489 | 0.022 | 0.489 | 0.524 | 0.000 | 0.364 | 0.000 | -0.011 | 0.776 | 0.002 | 0.959 | 0.277 | 0.024 | 0.279 | 0.034 | |
TGFB1 (TGFβ) | 0.119 | 0.000 | 0.117 | 0.000 | 0.513 | 0.000 | 0.348 | 0.000 | -0.075 | 0.061 | -0.088 | 0.041 | 0.153 | 0.214 | 0.161 | 0.228 | |
T cell exhaustion | PD-1 (PDCD1) | -0.142 | 0.000 | -0.171 | 0.000 | 0.319 | 0.000 | 0.087 | 0.326 | -0.054 | 0.179 | -0.04 | 0.35 | -0.098 | 0.43 | -0.093 | 0.486 |
CTLA4 | -0.179 | 0.000 | -0.199 | 0.000 | 0.428 | 0.000 | 0.208 | 0.019 | -0.069 | 0.086 | -0.046 | 0.282 | -0.028 | 0.819 | -0.06 | 0.654 | |
LAG3 | -0.241 | 0.000 | -0.248 | 0.000 | 0.341 | 0.000 | 0.148 | 0.095 | -0.096 | 0.017 | -0.068 | 0.114 | -0.032 | 0.799 | -0.07 | 0.602 | |
TIM-3 (HAVCR2) | 0.047 | 0.12 | 0.035 | 0.264 | 0.575 | 0.000 | 0.426 | 0.000 | -0.015 | 0.716 | -0.015 | 0.724 | 0.128 | 0.302 | 0.131 | 0.329 | |
GZMB | -0.243 | 0.000 | -0.279 | 0.000 | 0.349 | 0.000 | 0.144 | 0.105 | -0.09 | 0.026 | -0.085 | 0.048 | -0.093 | 0.452 | -0.111 | 0.407 |