Table 1 Correlation of ITPR1 mRNA expression and clinicopathological factors in Breast cancer by Kaplan–Meier plotter database
Variables of breast cancer | Overall survival (n = 1880) | Relapse free survival (n = 4929) | ||||
|---|---|---|---|---|---|---|
N | Hazard ratio | P-value | N | Hazard ratio | P-value | |
ER | ||||||
 Positive | 754 | 0.69 (0.5–0.94) | 0.017 | 2633 | 0.66 (0.55–0.8) |  < 0.0001 |
 Negative | 520 | 0.63 (0.41–0.96) | 0.031 | 1190 | 1.21 (0.97–1.5) | 0.087 |
PR | ||||||
 Positive | 156 | 2.37 (0.9–6.25) | 0.071 | 926 | 0.56 (0.39–0.8) | 0.0011 |
 Negative | 291 | 0.53 (0.29–0.98) | 0.039 | 925 | 0.76 (0.59–0.99) | 0.04 |
HER2 | ||||||
 Positive | 420 | 0.6 (0.41–0.88) | 0.0086 | 882 | 0.86 (0.68–1.08) | 0.19 |
 Negative | 1459 | 0.58 (0.46–0.72) |  < 0.0001 | 4047 | 0.62 (0.56–0.7) |  < 0.0001 |
Intrinsic subtype | ||||||
 basal | 404 | 0.63 (0.39–1.02) | 0.058 | 846 | 1.3 (1.03–1.65) | 0.027 |
 luminal A | 794 | 0.57 (0.41–0.79) | 0.00056 | 2277 | 0.64 (0.53–0.76) |  < 0.0001 |
 luminal B | 515 | 0.76 (0.52–1.11) | 0.16 | 1491 | 0.8 (0.66–0.98) | 0.032 |
 HER2 +  | 166 | 0.48 (0.27–0.86) | 0.011 | 315 | 0.74 (0.5–1.08) | 0.12 |
Lymph node status | ||||||
 Positive | 452 | 0.69 (0.48–0.99) | 0.046 | 1656 | 0.67 (0.55–0.81) |  < 0.0001 |
 Negative | 722 | 0.53 (0.37–0.78) | 0.00087 | 2368 | 0.63 (0.54–0.75) |  < 0.0001 |
Grade | ||||||
 1 | 175 | 0.52 (0.17–1.56) | 0.23 | 397 | 0.56 (0.31–1) | 0.046 |
 2 | 443 | 0.6 (0.4–0.9) | 0.012 | 1177 | 0.61 (0.49–076) |  < 0.0001 |
 3 | 586 | 0.85 (0.63–1.16) | 0.31 | 1300 | 1.27 (1.01–1.59) | 0.041 |
TP53 mutation | ||||||
 Positive | 130 | 0.73 (0.38–1.42) | 0.36 | 188 | 0.63 (0.38–1.05) | 0.071 |
 Negative | 197 | 0.44 (0.23–0.81) | 0.0068 | 273 | 0.61 (0.4–0.93) | 0.021 |