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Table 1 Correlation of ITPR1 mRNA expression and clinicopathological factors in Breast cancer by Kaplan–Meier plotter database

From: Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer

Variables of breast cancer Overall survival (n = 1880) Relapse free survival (n = 4929)
N Hazard ratio P-value N Hazard ratio P-value
ER
 Positive 754 0.69 (0.5–0.94) 0.017 2633 0.66 (0.55–0.8)  < 0.0001
 Negative 520 0.63 (0.41–0.96) 0.031 1190 1.21 (0.97–1.5) 0.087
PR
 Positive 156 2.37 (0.9–6.25) 0.071 926 0.56 (0.39–0.8) 0.0011
 Negative 291 0.53 (0.29–0.98) 0.039 925 0.76 (0.59–0.99) 0.04
HER2
 Positive 420 0.6 (0.41–0.88) 0.0086 882 0.86 (0.68–1.08) 0.19
 Negative 1459 0.58 (0.46–0.72)  < 0.0001 4047 0.62 (0.56–0.7)  < 0.0001
Intrinsic subtype
 basal 404 0.63 (0.39–1.02) 0.058 846 1.3 (1.03–1.65) 0.027
 luminal A 794 0.57 (0.41–0.79) 0.00056 2277 0.64 (0.53–0.76)  < 0.0001
 luminal B 515 0.76 (0.52–1.11) 0.16 1491 0.8 (0.66–0.98) 0.032
 HER2 +  166 0.48 (0.27–0.86) 0.011 315 0.74 (0.5–1.08) 0.12
Lymph node status
 Positive 452 0.69 (0.48–0.99) 0.046 1656 0.67 (0.55–0.81)  < 0.0001
 Negative 722 0.53 (0.37–0.78) 0.00087 2368 0.63 (0.54–0.75)  < 0.0001
Grade
 1 175 0.52 (0.17–1.56) 0.23 397 0.56 (0.31–1) 0.046
 2 443 0.6 (0.4–0.9) 0.012 1177 0.61 (0.49–076)  < 0.0001
 3 586 0.85 (0.63–1.16) 0.31 1300 1.27 (1.01–1.59) 0.041
TP53 mutation
 Positive 130 0.73 (0.38–1.42) 0.36 188 0.63 (0.38–1.05) 0.071
 Negative 197 0.44 (0.23–0.81) 0.0068 273 0.61 (0.4–0.93) 0.021