Table 4 Association of clinicopathological features with DR, TB, and TILs in biopsy specimens
Desmoplastic reaction | Budding | Tumor-infiltrating lymphocytes | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature | (%) | Immature | (%) | p-value | Low | (%) | High | (%) | p-value | High | (%) | Low | % | p-value | |
Sex | 0.44 | 0.62 | 0.5 | ||||||||||||
Female | 13 | (39) | 20 | (61) | 26 | (79) | 7 | (21) | 19 | (58) | 14 | (42) | |||
Male | 24 | (48) | 26 | (52) | 37 | (74) | 13 | (26) | 25 | (50) | 25 | (50) | |||
Age, years | 0.53 | 0.51 | 0.68 | ||||||||||||
  < 63 | 12 | (40) | 18 | 60) | 24 | (80) | 6 | (20) | 15 | (50) | 15 | (50) | |||
  ≥ 64 | 25 | (47) | 28 | (53) | 39 | (74) | 14 | (26) | 29 | (55) | 24 | (45) | |||
Location | 0.7 | 0.6 | 0.73 | ||||||||||||
Palate | 1 | (100) | 0 | (0) | 1 | (100) | 0 | (0) | 1 | (100) | 0 | (0) | |||
Oral floor | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | |||
Gingiva | 6 | (43) | 8 | (57) | 12 | (86) | 2 | (14) | 7 | (50) | 7 | (50) | |||
Tongue | 26 | (43) | 34 | (57) | 45 | (75) | 15 | (25) | 31 | (52) | 29 | (48) | |||
Buccal mucosa | 4 | (50) | 4 | (50) | 5 | (62) | 3 | (38) | 5 | (63) | 3 | (38) | |||
cDOI |  < 0.001 | 0.28 |  < 0.01 | ||||||||||||
  ≤ 5 mm | 25 | (86) | 4 | (14) | 24 | (83) | 5 | (17) | 22 | (76) | 7 | (24) | |||
  > 5 mm | 12 | (22) | 42 | (78) | 39 | (72) | 15 | (328) | 22 | (41) | 32 | (59) | |||
cDOI |  < 0.001 | 0.1 |  < 0.001 | ||||||||||||
 ≤ 10 mm | 29 | (69) | 13 | (31) | 35 | (83) | 7 | (17) | 31 | (74) | 11 | (26) | |||
  > 10 mm | 8 | (20) | 33 | (80) | 28 | (68) | 13 | (32) | 13 | (32) | 28 | (68) | |||
Metastasis |  < 0.01 | 0.41 |  < 0.01 | ||||||||||||
Absent | 31 | (55) | 25 | (45) | 44 | (79) | 12 | (21) | 36 | (64) | 20 | (36) | |||
Present | 6 | (22) | 21 | (78) | 19 | (70) | 8 | (30) | 8 | (30) | 19 | (70) | |||
Number of LNs | 0.02 | 0.049 | 0.01 | ||||||||||||
n = 0 | 31 | (55) | 25 | (45) | 44 | (79) | 12 | (21) | 36 | (64) | 20 | (36) | |||
n = 1 | 2 | (17) | 10 | (83) | 11 | (92) | 1 | (8) | 3 | (25) | 9 | (75) | |||
n≧2 | 4 | (27) | 11 | (73) | 8 | (53) | 7 | (47) | 5 | (33) | 10 | (67) | |||
pT |  < 0.001 | 0.06 |  < 0.001 | ||||||||||||
1, 2 | 27 | (75) | 9 | (25) | 31 | (86) | 5 | (14) | 27 | (75) | 9 | (25) | |||
3, 4 | 10 | (21) | 37 | (79) | 32 | (68) | 15 | (32) | 17 | (36) | 30 | (64) | |||
pN | 0.02 | 0.2 | 0.01 | ||||||||||||
0 | 31 | (55) | 25 | (45) | 44 | (79) | 12 | (21) | 36 | (64) | 20 | (36) | |||
1 | 2 | (22) | 7 | (78) | 8 | (89) | 1 | (11) | 2 | (22) | 7 | (78) | |||
2, 3 | 4 | (22) | 14 | (78) | 11 | (61) | 7 | (39) | 6 | (33) | 12 | (67) | |||