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Table 2 Association of clinicopathological features with DR, TB, and TILs using surgically resected specimens

From: Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

 

Desmoplastic reaction

Tumor budding

Tumor-infiltrating lymphocytes

 

Mature

(%)

Immature

(%)

p-value

Low

(%)

High

(%)

p-value

High

(%)

Low

%

p-value

Sex

    

0.81

    

0.19

    

0.06

  Female

29

(41)

42

(59)

 

53

(75)

18

(25)

 

44

(62)

27

(38)

 

  Male

49

(43)

66

(57)

 

95

(83)

20

(17)

 

55

(48)

60

(52)

 

Age, years

    

0.17

    

 < 0.001

    

0.59

   < 65

28

(49)

29

(50)

 

41

(72)

16

(28)

 

32

(56)

25

(44)

 

   ≥ 65

50

(39)

79

(61)

 

107

(83)

22

(17)

 

67

(52)

62

(48)

 

Location

    

0.63

    

0.6

    

0.36

  Palate

3

(75)

1

(21)

 

4

(100)

0

(0)

 

3

(75)

1

(25)

 

  Oral floor

1

(33)

2

(60)

 

3

(100)

0

(0)

 

2

(67)

1

(33)

 

  Gingiva

12

(41)

17

(58)

 

22

(76)

7

(24)

 

11

(38)

18

(62)

 

  Tongue

55

(43)

74

(57)

 

101

(78)

28

(22)

 

70

(54)

59

(46)

 

  Buccal mucosa

7

(33)

14

(66)

 

18

(86)

3

(14)

 

13

(62)

8

(38)

 

pDOI

    

 < 0.001

    

0.06

    

 < 0.001

   ≥ 5 mm

46

(73)

17

(27)

 

55

(87)

8

(13)

 

49

(78)

14

(22)

 

   < 5 mm

32

(26)

91

(74)

 

93

(76)

30

(24)

 

50

(41)

73

(59)

 

pDOI

    

 < 0.001

    

0.01

    

 < 0.001

   ≥ 10 mm

57

(56)

45

(44)

 

88

(86)

14

(14)

 

72

(71)

30

(29)

 

   < 10 mm

21

(25)

63

(75)

 

60

(71)

24

(29)

 

27

(32)

57

(68)

 

Metastasis

    

 < 0.001

    

0.02

    

 < 0.001

  Absent

68

(53)

60

(47)

 

108

(84)

20

(16)

 

79

(62)

49

(38)

 

  Present

10

(17)

48

(83)

 

40

(69)

18

(31)

 

20

(34)

38

(66)

 

Number of LNs

    

 < 0.001

    

0.03

    

 < 0.001

  n = 0

68

(53)

60

(47)

 

108

(84)

20

(16)

 

79

(62)

49

(38)

 

  n = 1

5

(23)

16

(76)

 

16

(76)

5

(24)

 

10

(48)

11

(52)

 

  n > 2

5

(13)

32

(86)

 

24

(65)

13

(35)

 

10

(27)

27

(73)

 

Pattern of invasion

    

 < 0.001

    

0.01

    

 < 0.01

  1, 2

30

(70)

13

(30)

 

40

(93)

3

(7)

 

31

(72)

12

(28)

 

  3, 4

48

(34)

95

(66)

 

108

(76)

35

(24)

 

68

(48)

75

(52)

 

LyV

    

 < 0.001

    

0.03

    

 < 0.001

  Absent

44

(60)

29

(39)

 

64

(88)

9

(12)

 

50

(68)

23

(32)

 

  Present

34

(30)

79

(70)

 

84

(74)

29

(26)

 

49

(43)

64

(57)

 

pT

    

 < 0.001

    

0.01

    

 < 0.001

  1, 2

54

(59)

38

(41)

 

80

(87)

12

(13)

 

67

(73)

25

(27)

 

  3. 4

24

(26)

70

(74)

 

68

(72)

26

(28)

 

32

(34)

62

(66)

 

pN

    

 < 0.001

    

0.02

    

 < 0.01

  0

68

(53)

60

(47)

 

108

(84)

20

(16)

 

79

(42)

49

(41)

 

  1,

3

(19)

13

(81)

 

13

(81)

3

(19)

 

6

(37)

10

(63)

 

  2, 3

7

(17)

35

(83)

 

27

(64)

15

(36)

 

14

(33)

28

(67)

 
  1. OSCC Oral squamous cell carcinoma, DR Desmoplastic reaction, TB Tumor budding, TILs Tumor-infiltrating lymphocytes, pDOI pathological depth of invasion, LN lymph nodes, LyV lymphovascular invasion, pT pathological T, pN pathological N. Boldface indicates statistically significant values
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BMC Cancer

ISSN: 1471-2407

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